Genetic risk for Alzheimer’s disease is concentrated in specific macrophage and microglial transcriptional networks

Genetic risk for Alzheimer’s disease is concentrated in specific macrophage and microglial transcriptional networks

Abstract Background Genome-wide association studies of Alzheimer’s disease (AD) have identified a number of significant risk loci, the majority of which lie in non-coding regions of the genome. The lack of causal alleles and considerable polygenicity remains a significant barrier to translation into...

Full description

Bibliographic Details
Main Authors: Katherine E. Tansey, Darren Cameron, Matthew J. Hill
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Genome Medicine
Subjects:
Alzheimer’s disease
GWAS
Transcription factor
Non-coding variation
Online Access:http://link.springer.com/article/10.1186/s13073-018-0523-8

Internet

http://link.springer.com/article/10.1186/s13073-018-0523-8

Similar Items