Predict drug sensitivity of cancer cells with pathway activity inference

Predict drug sensitivity of cancer cells with pathway activity inference

Abstract Background Predicting cellular responses to drugs has been a major challenge for personalized drug therapy regimen. Recent pharmacogenomic studies measured the sensitivities of heterogeneous cell lines to numerous drugs, and provided valuable data resources to develop and validate computati...

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Bibliographic Details
Main Authors: Xuewei Wang, Zhifu Sun, Michael T. Zimmermann, Andrej Bugrim, Jean-Pierre Kocher
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Medical Genomics
Subjects:
Pathway activity
Drug sensitivity
Precision therapy
Machine learning
Cancer
Pharmacogenomics
Online Access:http://link.springer.com/article/10.1186/s12920-018-0449-4

Internet

http://link.springer.com/article/10.1186/s12920-018-0449-4

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