HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.

HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.

The T cell immunoglobulin mucin 3 (Tim-3) receptor is highly expressed on HIV-1-specific T cells, rendering them partially "exhausted" and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurologic...

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Bibliographic Details
Main Authors: Lishomwa C Ndhlovu, Fabio E Leal, Aaron M Hasenkrug, Aashish R Jha, Karina I Carvalho, Ijeoma G Eccles-James, Fernanda R Bruno, Raphaella G S Vieira, Vanessa A York, Glen M Chew, R Brad Jones, Yuetsu Tanaka, Walter K Neto, Sabri S Sanabani, Mario A Ostrowski, Aluisio C Segurado, Douglas F Nixon, Esper G Kallas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3082508?pdf=render

Internet

http://europepmc.org/articles/PMC3082508?pdf=render

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