A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2

Continuous low-level supply or in situ generation of hydrogen peroxide (H2O2) is essential for the stability of unspecific peroxygenases. Here, the authors demonstrate that AuPd / TiO2 can generate sufficient H2O2 for the engineered unspecific heme-thiolate peroxygenase PaDa-I to oxidise a range of...

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Bibliographic Details
Main Authors: Simon J. Freakley, Svenja Kochius, Jacqueline van Marwijk, Caryn Fenner, Richard J. Lewis, Kai Baldenius, Sarel S. Marais, Diederik J. Opperman, Susan T. L. Harrison, Miguel Alcalde, Martha S. Smit, Graham J. Hutchings
Format: Article
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12120-w