The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

<p>Abstract</p> <p>Background</p> <p>The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD). Clinical development of BACE1 inhibitors is bein...

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Bibliographic Details
Main Authors: Rajapaksha Tharinda W, Eimer William A, Bozza Thomas C, Vassar Robert
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Molecular Neurodegeneration
Subjects:
Aβ
BACE1
β-amyloid
β-secretase
Alzheimer's disease
axon guidance
axon targeting
glomerulus
odorant receptor
olfactory sensory neuron
olfactory bulb
olfactory system
Online Access:http://www.molecularneurodegeneration.com/content/6/1/88

Internet

http://www.molecularneurodegeneration.com/content/6/1/88

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