Application of mesoporous silica nanoparticles for drug delivery to cancer cells
Cancer is one of the main causes of death worldwide. Chemotherapy is the most common method for cancer therapy which represent non-specific side effects on normal cells and tissues and drug resistance in cancer cells. There are two main mechanisms for Multi Drug Resistance (MDR) in cancer cells incl...
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Birjand University of Medical Sciences and Health Services
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doaj-19a25e09a2b24e518955726fcc48de282020-11-25T03:42:30ZfasBirjand University of Medical Sciences and Health ServicesJournal of Birjand University of Medical Sciences1607-21972423-61522020-09-01273220230Application of mesoporous silica nanoparticles for drug delivery to cancer cellsBizhan Malaekeh-Nikouei0Mohammad Yahya Hanafi-Bojd1 Nanotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran & Nanomedicine Department, faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran. Cancer is one of the main causes of death worldwide. Chemotherapy is the most common method for cancer therapy which represent non-specific side effects on normal cells and tissues and drug resistance in cancer cells. There are two main mechanisms for Multi Drug Resistance (MDR) in cancer cells including: drug efflux pump and activation of anti-apoptotic pathways. Cancer chemotherapy disadvantages can be overcome by using nanoparticulate drug delivery systems like Mesoporous Silica Nanoparticles (MSNs) that have been used as drug delivery system since 2001. The present review included synthesis, targeted (active or passive) drug delivery to cancer cells, co-delivery of anticancer drugs and siRNA by MSNs and its toxicity. This review revealed that MSNs are good candidate for drug delivery to cancer cells due to its unique properties including: controllable pore and particle sizes, thermal and chemical stability, modifications of outer and inner surfaces of nanoparticles for drug and siRNA loading, attachment of ligand for targeted drug delivery, high drug loading capacity and controlled drug release, biocompatibility and biodegradation in aqueous medium.http://journal.bums.ac.ir/article-1-2817-en.htmlcancermesoporous silica nanoparticles (msns)targeted drug delivery |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Bizhan Malaekeh-Nikouei Mohammad Yahya Hanafi-Bojd |
spellingShingle |
Bizhan Malaekeh-Nikouei Mohammad Yahya Hanafi-Bojd Application of mesoporous silica nanoparticles for drug delivery to cancer cells Journal of Birjand University of Medical Sciences cancer mesoporous silica nanoparticles (msns) targeted drug delivery |
author_facet |
Bizhan Malaekeh-Nikouei Mohammad Yahya Hanafi-Bojd |
author_sort |
Bizhan Malaekeh-Nikouei |
title |
Application of mesoporous silica nanoparticles for drug delivery to cancer cells |
title_short |
Application of mesoporous silica nanoparticles for drug delivery to cancer cells |
title_full |
Application of mesoporous silica nanoparticles for drug delivery to cancer cells |
title_fullStr |
Application of mesoporous silica nanoparticles for drug delivery to cancer cells |
title_full_unstemmed |
Application of mesoporous silica nanoparticles for drug delivery to cancer cells |
title_sort |
application of mesoporous silica nanoparticles for drug delivery to cancer cells |
publisher |
Birjand University of Medical Sciences and Health Services |
series |
Journal of Birjand University of Medical Sciences |
issn |
1607-2197 2423-6152 |
publishDate |
2020-09-01 |
description |
Cancer is one of the main causes of death worldwide. Chemotherapy is the most common method for cancer therapy which represent non-specific side effects on normal cells and tissues and drug resistance in cancer cells. There are two main mechanisms for Multi Drug Resistance (MDR) in cancer cells including: drug efflux pump and activation of anti-apoptotic pathways. Cancer chemotherapy disadvantages can be overcome by using nanoparticulate drug delivery systems like Mesoporous Silica Nanoparticles (MSNs) that have been used as drug delivery system since 2001. The present review included synthesis, targeted (active or passive) drug delivery to cancer cells, co-delivery of anticancer drugs and siRNA by MSNs and its toxicity. This review revealed that MSNs are good candidate for drug delivery to cancer cells due to its unique properties including: controllable pore and particle sizes, thermal and chemical stability, modifications of outer and inner surfaces of nanoparticles for drug and siRNA loading, attachment of ligand for targeted drug delivery, high drug loading capacity and controlled drug release, biocompatibility and biodegradation in aqueous medium. |
topic |
cancer mesoporous silica nanoparticles (msns) targeted drug delivery |
url |
http://journal.bums.ac.ir/article-1-2817-en.html |
work_keys_str_mv |
AT bizhanmalaekehnikouei applicationofmesoporoussilicananoparticlesfordrugdeliverytocancercells AT mohammadyahyahanafibojd applicationofmesoporoussilicananoparticlesfordrugdeliverytocancercells |
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