Smooth muscle myosin inhibition: a novel therapeutic approach for pulmonary hypertension.

Smooth muscle myosin inhibition: a novel therapeutic approach for pulmonary hypertension.

Pulmonary hypertension remains a major clinical problem despite current therapies. In this study, we examine for the first time a novel pharmacological target, smooth muscle myosin, and determine if the smooth muscle myosin inhibitor, CK-2019165 (CK-165) ameliorates pulmonary hypertension.Six domest...

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Bibliographic Details
Main Authors: David Ho, Li Chen, Xin Zhao, Nicquanna Durham, Malar Pannirselvam, Dorothy E Vatner, David J Morgans, Fady I Malik, Stephen F Vatner, You-Tang Shen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3341368?pdf=render

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http://europepmc.org/articles/PMC3341368?pdf=render

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