Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report

<p>Abstract</p> <p>Introduction</p> <p>Primary signet-ring cell carcinoma of the urinary bladder is a rare variant of mucus-producing adenocarcinoma constituting approximately 0.5% to 2.0% of all primary carcinomas of the bladder. This tumor initially presents as a high...

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Main Authors: El Ammari Jalal Eddine, Ahsaini Mustapha, Riyach Omar, El Fassi Mohammed Jamal, Farih My Hassan, Hammas Nawal, Elfatmi Hind, Amarti Afaf
Format: Article
Language:English
Published: BMC 2013-02-01
Series:Journal of Medical Case Reports
Subjects:
Online Access:http://www.jmedicalcasereports.com/content/7/1/37
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spelling doaj-1b2576f6dfce44338233a6563e7a94a82020-11-25T00:55:22ZengBMCJournal of Medical Case Reports1752-19472013-02-01713710.1186/1752-1947-7-37Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case reportEl Ammari Jalal EddineAhsaini MustaphaRiyach OmarEl Fassi Mohammed JamalFarih My HassanHammas NawalElfatmi HindAmarti Afaf<p>Abstract</p> <p>Introduction</p> <p>Primary signet-ring cell carcinoma of the urinary bladder is a rare variant of mucus-producing adenocarcinoma constituting approximately 0.5% to 2.0% of all primary carcinomas of the bladder. This tumor initially presents as a high-grade, high-stage lesion and diffusely invades the bladder wall without forming intraluminal growth. The patients have no specific symptoms, which leads to delayed diagnosis and poor prognosis.</p> <p>Case presentation</p> <p>We report the case of a 51-year-old Moroccan Berber man consulting for gross hematuria. Ultrasonography and a computed tomography scan found a bladder tumor diffusely invading the bladder wall. A histopathological examination of the tumor chips from a transurethral resection of the bladder revealed signet-ring cell adenocarcinoma. The gastrointestinal tract exploration did not reveal any other tumor localization. A radical cystectomy and adjuvant cisplatin and gemcitabine chemotherapy were therefore performed resulting in 18 months of survival without metastasis and a good quality of life within that time.</p> <p>Conclusion</p> <p>The rarity and the successful management with carboplatin and gemcitabine as adjuvant chemotherapy of this entity, which is rarely reported in the literature, are two remarkable characteristics described in this case report.</p> http://www.jmedicalcasereports.com/content/7/1/37Primary signet-ring cell carcinomaAdenocarcinomaUrinary bladderChemotherapy
collection DOAJ
language English
format Article
sources DOAJ
author El Ammari Jalal Eddine
Ahsaini Mustapha
Riyach Omar
El Fassi Mohammed Jamal
Farih My Hassan
Hammas Nawal
Elfatmi Hind
Amarti Afaf
spellingShingle El Ammari Jalal Eddine
Ahsaini Mustapha
Riyach Omar
El Fassi Mohammed Jamal
Farih My Hassan
Hammas Nawal
Elfatmi Hind
Amarti Afaf
Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report
Journal of Medical Case Reports
Primary signet-ring cell carcinoma
Adenocarcinoma
Urinary bladder
Chemotherapy
author_facet El Ammari Jalal Eddine
Ahsaini Mustapha
Riyach Omar
El Fassi Mohammed Jamal
Farih My Hassan
Hammas Nawal
Elfatmi Hind
Amarti Afaf
author_sort El Ammari Jalal Eddine
title Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report
title_short Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report
title_full Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report
title_fullStr Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report
title_full_unstemmed Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report
title_sort primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report
publisher BMC
series Journal of Medical Case Reports
issn 1752-1947
publishDate 2013-02-01
description <p>Abstract</p> <p>Introduction</p> <p>Primary signet-ring cell carcinoma of the urinary bladder is a rare variant of mucus-producing adenocarcinoma constituting approximately 0.5% to 2.0% of all primary carcinomas of the bladder. This tumor initially presents as a high-grade, high-stage lesion and diffusely invades the bladder wall without forming intraluminal growth. The patients have no specific symptoms, which leads to delayed diagnosis and poor prognosis.</p> <p>Case presentation</p> <p>We report the case of a 51-year-old Moroccan Berber man consulting for gross hematuria. Ultrasonography and a computed tomography scan found a bladder tumor diffusely invading the bladder wall. A histopathological examination of the tumor chips from a transurethral resection of the bladder revealed signet-ring cell adenocarcinoma. The gastrointestinal tract exploration did not reveal any other tumor localization. A radical cystectomy and adjuvant cisplatin and gemcitabine chemotherapy were therefore performed resulting in 18 months of survival without metastasis and a good quality of life within that time.</p> <p>Conclusion</p> <p>The rarity and the successful management with carboplatin and gemcitabine as adjuvant chemotherapy of this entity, which is rarely reported in the literature, are two remarkable characteristics described in this case report.</p>
topic Primary signet-ring cell carcinoma
Adenocarcinoma
Urinary bladder
Chemotherapy
url http://www.jmedicalcasereports.com/content/7/1/37
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