Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report
<p>Abstract</p> <p>Introduction</p> <p>Primary signet-ring cell carcinoma of the urinary bladder is a rare variant of mucus-producing adenocarcinoma constituting approximately 0.5% to 2.0% of all primary carcinomas of the bladder. This tumor initially presents as a high...
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doaj-1b2576f6dfce44338233a6563e7a94a82020-11-25T00:55:22ZengBMCJournal of Medical Case Reports1752-19472013-02-01713710.1186/1752-1947-7-37Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case reportEl Ammari Jalal EddineAhsaini MustaphaRiyach OmarEl Fassi Mohammed JamalFarih My HassanHammas NawalElfatmi HindAmarti Afaf<p>Abstract</p> <p>Introduction</p> <p>Primary signet-ring cell carcinoma of the urinary bladder is a rare variant of mucus-producing adenocarcinoma constituting approximately 0.5% to 2.0% of all primary carcinomas of the bladder. This tumor initially presents as a high-grade, high-stage lesion and diffusely invades the bladder wall without forming intraluminal growth. The patients have no specific symptoms, which leads to delayed diagnosis and poor prognosis.</p> <p>Case presentation</p> <p>We report the case of a 51-year-old Moroccan Berber man consulting for gross hematuria. Ultrasonography and a computed tomography scan found a bladder tumor diffusely invading the bladder wall. A histopathological examination of the tumor chips from a transurethral resection of the bladder revealed signet-ring cell adenocarcinoma. The gastrointestinal tract exploration did not reveal any other tumor localization. A radical cystectomy and adjuvant cisplatin and gemcitabine chemotherapy were therefore performed resulting in 18 months of survival without metastasis and a good quality of life within that time.</p> <p>Conclusion</p> <p>The rarity and the successful management with carboplatin and gemcitabine as adjuvant chemotherapy of this entity, which is rarely reported in the literature, are two remarkable characteristics described in this case report.</p> http://www.jmedicalcasereports.com/content/7/1/37Primary signet-ring cell carcinomaAdenocarcinomaUrinary bladderChemotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
El Ammari Jalal Eddine Ahsaini Mustapha Riyach Omar El Fassi Mohammed Jamal Farih My Hassan Hammas Nawal Elfatmi Hind Amarti Afaf |
spellingShingle |
El Ammari Jalal Eddine Ahsaini Mustapha Riyach Omar El Fassi Mohammed Jamal Farih My Hassan Hammas Nawal Elfatmi Hind Amarti Afaf Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report Journal of Medical Case Reports Primary signet-ring cell carcinoma Adenocarcinoma Urinary bladder Chemotherapy |
author_facet |
El Ammari Jalal Eddine Ahsaini Mustapha Riyach Omar El Fassi Mohammed Jamal Farih My Hassan Hammas Nawal Elfatmi Hind Amarti Afaf |
author_sort |
El Ammari Jalal Eddine |
title |
Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report |
title_short |
Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report |
title_full |
Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report |
title_fullStr |
Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report |
title_full_unstemmed |
Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report |
title_sort |
primary signet-ring cell carcinoma of the urinary bladder successfully managed with cisplatin and gemcitabine: a case report |
publisher |
BMC |
series |
Journal of Medical Case Reports |
issn |
1752-1947 |
publishDate |
2013-02-01 |
description |
<p>Abstract</p> <p>Introduction</p> <p>Primary signet-ring cell carcinoma of the urinary bladder is a rare variant of mucus-producing adenocarcinoma constituting approximately 0.5% to 2.0% of all primary carcinomas of the bladder. This tumor initially presents as a high-grade, high-stage lesion and diffusely invades the bladder wall without forming intraluminal growth. The patients have no specific symptoms, which leads to delayed diagnosis and poor prognosis.</p> <p>Case presentation</p> <p>We report the case of a 51-year-old Moroccan Berber man consulting for gross hematuria. Ultrasonography and a computed tomography scan found a bladder tumor diffusely invading the bladder wall. A histopathological examination of the tumor chips from a transurethral resection of the bladder revealed signet-ring cell adenocarcinoma. The gastrointestinal tract exploration did not reveal any other tumor localization. A radical cystectomy and adjuvant cisplatin and gemcitabine chemotherapy were therefore performed resulting in 18 months of survival without metastasis and a good quality of life within that time.</p> <p>Conclusion</p> <p>The rarity and the successful management with carboplatin and gemcitabine as adjuvant chemotherapy of this entity, which is rarely reported in the literature, are two remarkable characteristics described in this case report.</p> |
topic |
Primary signet-ring cell carcinoma Adenocarcinoma Urinary bladder Chemotherapy |
url |
http://www.jmedicalcasereports.com/content/7/1/37 |
work_keys_str_mv |
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