Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability

Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability

Patients with monoallelic bromodomain and PHD finger-containing protein 1 (BRPF1) mutations showed intellectual disability. The hippocampus has essential roles in learning and memory. Our previous work indicated that Brpf1 was specifically and strongly expressed in the hippocampus from the perinatal...

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Bibliographic Details
Main Authors: Weiwei Xian, Jingli Cao, Xiangshan Yuan, Guoxiang Wang, Qiuyan Jin, Hang Zhang, Guomin Zhou, Linya You
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
intellectual disability
BRPF1
primary cultured hippocampal neurons
dendritic morphology
electrophysiology
stereotactic hippocampal injection
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.711792/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.711792/full

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