Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study
Problem. There was no direct correlation between plasma and placental oxidative damage parameters and inflammation and evidence of TLR4 pathway activation in the placenta in preeclamptic (PE) patients. Method of Study. 33 PE patients and 33 normotensive pregnant women were included. The maternal sec...
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doaj-1b8437d69c4e4e34a0c08032d30681852020-11-25T00:22:42ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942012-01-01201210.1155/2012/636419636419Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control StudyFabiana C. B. Bernardi0Francine Felisberto1Francieli Vuolo2Fabricia Petronilho3Daniela R. Souza4Thais F. Luciano5Cláudio T. de Souza6Cristiane Ritter7Felipe Dal-Pizzol8Laboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilLaboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, BrazilLaboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, BrazilLaboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilProblem. There was no direct correlation between plasma and placental oxidative damage parameters and inflammation and evidence of TLR4 pathway activation in the placenta in preeclamptic (PE) patients. Method of Study. 33 PE patients and 33 normotensive pregnant women were included. The maternal section of the placenta and blood were collected to the determination of oxidative damage markers (thiobarbituric acid reactive species and protein carbonyls), inflammatory response (interleukin-6 and myeloperoxidase activity), and activation of the TLR-4-NF-kB pathway. Results. An increase of IL-6 levels in both plasma and placenta was observed, but myeloperoxidase activity was not significantly different comparing the groups. Oxidative damage parameters were increased in plasma and placenta in PE patients. A significant increase of the protein levels of TLR-4 and NF-kB was observed in the placenta. Conclusion. The TLR4-NF-kB pathway is upregulated in PE, probably generating local and systemic inflammatory response that is followed by local and systemic oxidative damage.http://dx.doi.org/10.1155/2012/636419 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fabiana C. B. Bernardi Francine Felisberto Francieli Vuolo Fabricia Petronilho Daniela R. Souza Thais F. Luciano Cláudio T. de Souza Cristiane Ritter Felipe Dal-Pizzol |
spellingShingle |
Fabiana C. B. Bernardi Francine Felisberto Francieli Vuolo Fabricia Petronilho Daniela R. Souza Thais F. Luciano Cláudio T. de Souza Cristiane Ritter Felipe Dal-Pizzol Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study Oxidative Medicine and Cellular Longevity |
author_facet |
Fabiana C. B. Bernardi Francine Felisberto Francieli Vuolo Fabricia Petronilho Daniela R. Souza Thais F. Luciano Cláudio T. de Souza Cristiane Ritter Felipe Dal-Pizzol |
author_sort |
Fabiana C. B. Bernardi |
title |
Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study |
title_short |
Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study |
title_full |
Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study |
title_fullStr |
Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study |
title_full_unstemmed |
Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study |
title_sort |
oxidative damage, inflammation, and toll-like receptor 4 pathway are increased in preeclamptic patients: a case-control study |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2012-01-01 |
description |
Problem. There was no direct correlation between plasma and placental oxidative damage parameters and inflammation and evidence of TLR4 pathway activation in the placenta in preeclamptic (PE) patients. Method of Study. 33 PE patients and 33 normotensive pregnant women were included. The maternal section of the placenta and blood were collected to the determination of oxidative damage markers (thiobarbituric acid reactive species and protein carbonyls), inflammatory response (interleukin-6 and myeloperoxidase activity), and activation of the TLR-4-NF-kB pathway. Results. An increase of IL-6 levels in both plasma and placenta was observed, but myeloperoxidase activity was not significantly different comparing the groups. Oxidative damage parameters were increased in plasma and placenta in PE patients. A significant increase of the protein levels of TLR-4 and NF-kB was observed in the placenta. Conclusion. The TLR4-NF-kB pathway is upregulated in PE, probably generating local and systemic inflammatory response that is followed by local and systemic oxidative damage. |
url |
http://dx.doi.org/10.1155/2012/636419 |
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