Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study

Problem. There was no direct correlation between plasma and placental oxidative damage parameters and inflammation and evidence of TLR4 pathway activation in the placenta in preeclamptic (PE) patients. Method of Study. 33 PE patients and 33 normotensive pregnant women were included. The maternal sec...

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Main Authors: Fabiana C. B. Bernardi, Francine Felisberto, Francieli Vuolo, Fabricia Petronilho, Daniela R. Souza, Thais F. Luciano, Cláudio T. de Souza, Cristiane Ritter, Felipe Dal-Pizzol
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2012/636419
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spelling doaj-1b8437d69c4e4e34a0c08032d30681852020-11-25T00:22:42ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942012-01-01201210.1155/2012/636419636419Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control StudyFabiana C. B. Bernardi0Francine Felisberto1Francieli Vuolo2Fabricia Petronilho3Daniela R. Souza4Thais F. Luciano5Cláudio T. de Souza6Cristiane Ritter7Felipe Dal-Pizzol8Laboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilLaboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, BrazilLaboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, BrazilLaboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilLaboratório de Fisiopatologia Experimental and Instituto Nacional Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Avenida Universitária, 1105, 88806-000 Criciúma, SC, BrazilProblem. There was no direct correlation between plasma and placental oxidative damage parameters and inflammation and evidence of TLR4 pathway activation in the placenta in preeclamptic (PE) patients. Method of Study. 33 PE patients and 33 normotensive pregnant women were included. The maternal section of the placenta and blood were collected to the determination of oxidative damage markers (thiobarbituric acid reactive species and protein carbonyls), inflammatory response (interleukin-6 and myeloperoxidase activity), and activation of the TLR-4-NF-kB pathway. Results. An increase of IL-6 levels in both plasma and placenta was observed, but myeloperoxidase activity was not significantly different comparing the groups. Oxidative damage parameters were increased in plasma and placenta in PE patients. A significant increase of the protein levels of TLR-4 and NF-kB was observed in the placenta. Conclusion. The TLR4-NF-kB pathway is upregulated in PE, probably generating local and systemic inflammatory response that is followed by local and systemic oxidative damage.http://dx.doi.org/10.1155/2012/636419
collection DOAJ
language English
format Article
sources DOAJ
author Fabiana C. B. Bernardi
Francine Felisberto
Francieli Vuolo
Fabricia Petronilho
Daniela R. Souza
Thais F. Luciano
Cláudio T. de Souza
Cristiane Ritter
Felipe Dal-Pizzol
spellingShingle Fabiana C. B. Bernardi
Francine Felisberto
Francieli Vuolo
Fabricia Petronilho
Daniela R. Souza
Thais F. Luciano
Cláudio T. de Souza
Cristiane Ritter
Felipe Dal-Pizzol
Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study
Oxidative Medicine and Cellular Longevity
author_facet Fabiana C. B. Bernardi
Francine Felisberto
Francieli Vuolo
Fabricia Petronilho
Daniela R. Souza
Thais F. Luciano
Cláudio T. de Souza
Cristiane Ritter
Felipe Dal-Pizzol
author_sort Fabiana C. B. Bernardi
title Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study
title_short Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study
title_full Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study
title_fullStr Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study
title_full_unstemmed Oxidative Damage, Inflammation, and Toll-Like Receptor 4 Pathway Are Increased in Preeclamptic Patients: A Case-Control Study
title_sort oxidative damage, inflammation, and toll-like receptor 4 pathway are increased in preeclamptic patients: a case-control study
publisher Hindawi Limited
series Oxidative Medicine and Cellular Longevity
issn 1942-0900
1942-0994
publishDate 2012-01-01
description Problem. There was no direct correlation between plasma and placental oxidative damage parameters and inflammation and evidence of TLR4 pathway activation in the placenta in preeclamptic (PE) patients. Method of Study. 33 PE patients and 33 normotensive pregnant women were included. The maternal section of the placenta and blood were collected to the determination of oxidative damage markers (thiobarbituric acid reactive species and protein carbonyls), inflammatory response (interleukin-6 and myeloperoxidase activity), and activation of the TLR-4-NF-kB pathway. Results. An increase of IL-6 levels in both plasma and placenta was observed, but myeloperoxidase activity was not significantly different comparing the groups. Oxidative damage parameters were increased in plasma and placenta in PE patients. A significant increase of the protein levels of TLR-4 and NF-kB was observed in the placenta. Conclusion. The TLR4-NF-kB pathway is upregulated in PE, probably generating local and systemic inflammatory response that is followed by local and systemic oxidative damage.
url http://dx.doi.org/10.1155/2012/636419
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