Search for a Functional Genetic Variant Mimicking the Effect of SGLT2 Inhibitor Treatment

Search for a Functional Genetic Variant Mimicking the Effect of SGLT2 Inhibitor Treatment

SGLT2 inhibitors (SGLT2i) block renal glucose reabsorption. Due to the unexpected beneficial observations in type 2 diabetic patients potentially related to increased natriuresis, SGLT2i are also studied for heart failure treatment. This study aimed to identify genetic variants mimicking SGLT2i to f...

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Bibliographic Details
Main Authors: Siqi Wang, M. Abdullah Said, Hilde E. Groot, Peter J. van der Most, Chris H. L. Thio, Yordi J. van de Vegte, Niek Verweij, Harold Snieder, Pim van der Harst
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Genes
Subjects:
SGLT2 inhibitor
heart failure
UK Biobank
genetic variants
Online Access:https://www.mdpi.com/2073-4425/12/8/1174

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