Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

Abstract.: We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-expos...

Full description

Bibliographic Details
Main Authors: Takanori Akagi, Yuta Matsumura, Masaya Yasui, Emiko Minami, Hidemasa Inoue, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Kazue Mizumura, Makoto Tsuda, Hiroshi Kiyama, Kazuhide Inoue
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319300660

Internet

http://www.sciencedirect.com/science/article/pii/S1347861319300660

Similar Items