Interleukin-1 Receptor Antagonist Reduces Neonatal Lipopolysaccharide-Induced Long-Lasting Neurobehavioral Deficits and Dopaminergic Neuronal Injury in Adult Rats

Interleukin-1 Receptor Antagonist Reduces Neonatal Lipopolysaccharide-Induced Long-Lasting Neurobehavioral Deficits and Dopaminergic Neuronal Injury in Adult Rats

Our previous study showed that a single lipopolysaccharide (LPS) treatment to neonatal rats could induce a long-lasting neuroinflammatory response and dopaminergic system injury late in life. This is evidenced by a sustained activation of microglia and elevated interleukin-1β (IL-1β) levels, as well...

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Bibliographic Details
Main Authors: Yi Pang, Lu-Tai Tien, Hobart Zhu, Juying Shen, Camilla F. Wright, Tembra K. Jones, Samir A. Mamoon, Abhay J. Bhatt, Zhengwei Cai, Lir-Wan Fan
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:International Journal of Molecular Sciences
Subjects:
lipopolysaccharide
interleukin-1 receptor antagonist
dopaminergic neuronal injury
substantia nigra
microglia
Online Access:http://www.mdpi.com/1422-0067/16/4/8635

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http://www.mdpi.com/1422-0067/16/4/8635

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