A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary

A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary

A vaccine against congenital cytomegalovirus infection is a high priority. Guinea pig cytomegalovirus (GPCMV) is the only congenital CMV small animal model. GPCMV encodes essential glycoprotein complexes for virus entry (gB, gH/gL/gO, gM/gN) including a pentamer complex (gH/gL/GP129/GP131/GP133 or P...

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Bibliographic Details
Main Authors: K. Yeon Choi, Alistair McGregor
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
cytomegalovirus
congenital CMV
guinea pig
glycoprotein complex
gB
gH
Online Access:https://www.mdpi.com/1999-4915/13/8/1467

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