Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer

Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer

Abstract Cellular senescence can either support or inhibit cancer progression. Here, it is shown that intratumoral infiltration of CD8+ T cells is negatively associated with the proportion of senescent tumor cells in colorectal cancer (CRC). Gene expression analysis reveals increased expression of C...

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Bibliographic Details
Main Authors: Yong Won Choi, Young Hwa Kim, Seung Yeop Oh, Kwang Wook Suh, Young‐Sam Kim, Ga‐Yeon Lee, Jung Eun Yoon, Soon Sang Park, Young‐Kyoung Lee, Yoo Jung Park, Hong Seok Kim, So Hyun Park, Jang‐Hee Kim, Tae Jun Park
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Advanced Science
Subjects:
cancer immunotherapy
CD8+ T cells
colorectal cancers
CXCL12
senescent tumor cells
Online Access:https://doi.org/10.1002/advs.202002497

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