Mutual Enhancement of Opioid and Adrenergic Receptors by Combinations of Opioids and Adrenergic Ligands Is Reflected in Molecular Complementarity of Ligands: Drug Development Possibilities

Mutual Enhancement of Opioid and Adrenergic Receptors by Combinations of Opioids and Adrenergic Ligands Is Reflected in Molecular Complementarity of Ligands: Drug Development Possibilities

Crosstalk between opioid and adrenergic receptors is well characterized and due to interactions between second messenger systems, formation of receptor heterodimers, and extracellular allosteric binding regions. Both classes of receptors bind both sets of ligands. We propose here that receptor cross...

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Bibliographic Details
Main Authors: Robert Root-Bernstein, Beth Churchill, Miah Turke, Udaya K. Tiruttani Subhramanyam, Joerg Labahn
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
coevolution
interactome
opiate receptors
adrenergic receptors
opioids
enhancement
tachyphylaxis
fade
prevention
reversal
drug development
combination drugs
linked compounds
tethered drugs
Online Access:https://www.mdpi.com/1422-0067/20/17/4137

Internet

https://www.mdpi.com/1422-0067/20/17/4137

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