Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19

Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19

Abstract Background Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has been associated with neurological and neuropsychiatric illness in many individuals. We sought to further our understanding of the relationship between brain...

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Bibliographic Details
Main Authors: John F. Fullard, Hao-Chih Lee, Georgios Voloudakis, Shengbao Suo, Behnam Javidfar, Zhiping Shao, Cyril Peter, Wen Zhang, Shan Jiang, André Corvelo, Heather Wargnier, Emma Woodoff-Leith, Dushyant P. Purohit, Sadhna Ahuja, Nadejda M. Tsankova, Nathalie Jette, Gabriel E. Hoffman, Schahram Akbarian, Mary Fowkes, John F. Crary, Guo-Cheng Yuan, Panos Roussos
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Genome Medicine
Subjects:
Gene expression
Neuroinflammation
Prefrontal cortex
Choroid plexus
SARS-CoV-2
Microglia
Online Access:https://doi.org/10.1186/s13073-021-00933-8

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