Simple, mild, one-step labelling of proteins with gallium-68 using a tris(hydroxypyridinone) bifunctional chelator: a 68Ga-THP-scFv targeting the prostate-specific membrane antigen

Simple, mild, one-step labelling of proteins with gallium-68 using a tris(hydroxypyridinone) bifunctional chelator: a 68Ga-THP-scFv targeting the prostate-specific membrane antigen

Abstract Background Labelling proteins with gallium-68 using bifunctional chelators is often problematic because of unsuitably harsh labelling conditions such as low pH or high temperature and may entail post-labelling purification. To determine whether tris(hydroxypyridinone) (THP) bifunctional che...

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Bibliographic Details
Main Authors: Saima Nawaz, Gregory E. D. Mullen, Kavitha Sunassee, Jayanta Bordoloi, Philip J. Blower, James R. Ballinger
Format: Article
Language:English
Published: SpringerOpen 2017-10-01
Series:EJNMMI Research
Subjects:
Tris(hydroxypyridinone) (THP)
Prostate cancer (PCa)
PSMA
Gallium-68 (68Ga)
Single-chain antibody (scFv)
Online Access:http://link.springer.com/article/10.1186/s13550-017-0336-6

Internet

http://link.springer.com/article/10.1186/s13550-017-0336-6

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