Neuregulin-1 converts reactive astrocytes toward oligodendrocyte lineage cells via upregulating the PI3K-AKT-mTOR pathway to repair spinal cord injury

Neuregulin-1 converts reactive astrocytes toward oligodendrocyte lineage cells via upregulating the PI3K-AKT-mTOR pathway to repair spinal cord injury

Axonal demyelination is a consistent pathological characteristic of Spinal cord injury (SCI). Promoting differentiation of oligodendrocytes is of importance for remyelination. Conversion of reactive astrocytes with stem cell potential to oligodendrocytes is proposed as an innovative strategy for SCI...

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Bibliographic Details
Main Authors: Zhenfei Ding, Ce Dai, Lin Zhong, Rui Liu, Weilu Gao, Hui Zhang, Zongsheng Yin
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Spinal cord injury
Oligodendrocyte
Reactive astrocyte
Neuregulin-1
Remyelination
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220313615

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http://www.sciencedirect.com/science/article/pii/S0753332220313615

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