Role of Adenosine Deaminase in Patients with Erythematotelangiectatic Rosacea and Demodex folliculorum Positivity

Background: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. Demodex specie...

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Main Authors: Serpil SENER, Ulku KARAMAN, Tugba Raika KIRAN, Cemil COLAK, Ali ASLAN, Sahin DIREKEL
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2020-12-01
Series:Iranian Journal of Parasitology
Subjects:
Online Access:https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3188
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spelling doaj-1ed9ae9c7fc94807ad35c95519a1cb762021-09-11T05:05:35ZengTehran University of Medical SciencesIranian Journal of Parasitology1735-70202008-238X2020-12-0115410.18502/ijpa.v15i4.4870Role of Adenosine Deaminase in Patients with Erythematotelangiectatic Rosacea and Demodex folliculorum PositivitySerpil SENER0Ulku KARAMAN1Tugba Raika KIRAN2Cemil COLAK3Ali ASLAN4Sahin DIREKEL5Department of Dermatology, Faculty of Medicine, Inonu University, Malatya, TurkeyDepartment of Medical Parasitology, Faculty of Medicine, Ordu University, Ordu, TurkeyFaculty of Engineering and Natural Sciences Biomedical Engineering, Iskenderun Technical University, Hatay, TurkeyDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Inonu University, Malatya, TurkeyDepartment of Physiology, Faculty of Medicine, Ordu University, Ordu, TurkeyDepartment of Medical Microbiology, Faculty of Medicine, Giresun University, Giresun, Turkey Background: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. Demodex species have been reported to be transmitted between humans through close contact and to play a role in the pathogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micropapillary-pruritic dermatitis and blepharitis. The present study aimed to compare serum ADA levels in D. folliculorum positive patients with the healthy control individuals. Methods: Serum ADA levels were examined for 30 patients diagnosed with erythematotelangiectatic rosacea and 40 healthy individuals in Malatya Inonu University in 2017. Standardized skin surface biopsy (SSSB) method was used to diagnose D. folliculorum. A significant decrease was found in the ADA levels of Demodex-positive rosacea patients when compared to the control group. Results: ADA levels were decreased in the Demodex-positive group. The mean ADA level in patient group was significantly lower than the mean in the control group (P<0.001). There was no significant difference between the patient and control groups in terms of age and gender. Conclusion: During and after treatment of Demodex-positive rosacea patients, determination of ADA levels may give more detailed information on the immune mechanisms. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3188ADA levelDemodex folliculorumErythematotelangiectatic rosacea
collection DOAJ
language English
format Article
sources DOAJ
author Serpil SENER
Ulku KARAMAN
Tugba Raika KIRAN
Cemil COLAK
Ali ASLAN
Sahin DIREKEL
spellingShingle Serpil SENER
Ulku KARAMAN
Tugba Raika KIRAN
Cemil COLAK
Ali ASLAN
Sahin DIREKEL
Role of Adenosine Deaminase in Patients with Erythematotelangiectatic Rosacea and Demodex folliculorum Positivity
Iranian Journal of Parasitology
ADA level
Demodex folliculorum
Erythematotelangiectatic rosacea
author_facet Serpil SENER
Ulku KARAMAN
Tugba Raika KIRAN
Cemil COLAK
Ali ASLAN
Sahin DIREKEL
author_sort Serpil SENER
title Role of Adenosine Deaminase in Patients with Erythematotelangiectatic Rosacea and Demodex folliculorum Positivity
title_short Role of Adenosine Deaminase in Patients with Erythematotelangiectatic Rosacea and Demodex folliculorum Positivity
title_full Role of Adenosine Deaminase in Patients with Erythematotelangiectatic Rosacea and Demodex folliculorum Positivity
title_fullStr Role of Adenosine Deaminase in Patients with Erythematotelangiectatic Rosacea and Demodex folliculorum Positivity
title_full_unstemmed Role of Adenosine Deaminase in Patients with Erythematotelangiectatic Rosacea and Demodex folliculorum Positivity
title_sort role of adenosine deaminase in patients with erythematotelangiectatic rosacea and demodex folliculorum positivity
publisher Tehran University of Medical Sciences
series Iranian Journal of Parasitology
issn 1735-7020
2008-238X
publishDate 2020-12-01
description Background: Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. Demodex species have been reported to be transmitted between humans through close contact and to play a role in the pathogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micropapillary-pruritic dermatitis and blepharitis. The present study aimed to compare serum ADA levels in D. folliculorum positive patients with the healthy control individuals. Methods: Serum ADA levels were examined for 30 patients diagnosed with erythematotelangiectatic rosacea and 40 healthy individuals in Malatya Inonu University in 2017. Standardized skin surface biopsy (SSSB) method was used to diagnose D. folliculorum. A significant decrease was found in the ADA levels of Demodex-positive rosacea patients when compared to the control group. Results: ADA levels were decreased in the Demodex-positive group. The mean ADA level in patient group was significantly lower than the mean in the control group (P<0.001). There was no significant difference between the patient and control groups in terms of age and gender. Conclusion: During and after treatment of Demodex-positive rosacea patients, determination of ADA levels may give more detailed information on the immune mechanisms.
topic ADA level
Demodex folliculorum
Erythematotelangiectatic rosacea
url https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3188
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