Prevention of propofol injection pain: Comparison between lidocaine and ramosetron
Background: Propofol causes a high incidence of pain during intravenous (IV) injection. The aim of this randomized, placebo-controlled, double-blinded study was to determine whether pre-treatment with IV ramosetron, used for prophylaxis of postoperative nausea and vomiting (PONV), would reduce propo...
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doaj-1f3c8fa9483d4901b6a1390c361275c42020-11-24T21:15:35ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852014-01-0130221321610.4103/0970-9185.130023Prevention of propofol injection pain: Comparison between lidocaine and ramosetronDipali SinghSathyanarayan JagannathShio PriyeShivaprakashChandrashekar KadliDurgaprasad ReddyBackground: Propofol causes a high incidence of pain during intravenous (IV) injection. The aim of this randomized, placebo-controlled, double-blinded study was to determine whether pre-treatment with IV ramosetron, used for prophylaxis of postoperative nausea and vomiting (PONV), would reduce propofol-induced pain as an equivalent to lidocaine. Materials and Methods: Hundred and twenty American Society of Anesthesiologists grade (ASA) I and II patients were randomly assigned into three groups (40 in each). Group N received 2 ml of 0.9% saline, Group L received 2 ml of lidocaine, and Group R received 2 ml of ramosetron. Mid forearm was occluded manually before injection and released after 1 min and then propofol was injected over 5 s. Patients were observed and questioned 15 s later if they had pain in the arm and pain was scored on a four-point scale: 0 = no pain, 1 = mild pain, 2 = moderate pain, and 3 = severe pain. Unpaired Student′s t-test and chi-square test/Fisher′ exact test were used to analyze results. Results: The incidence of pain in groups N, L, and R were 65, 35, and 30%, respectively. Pain was reduced significantly in the groups L and R (P < 0.05). Two patients each in Groups L and R (5% each) had moderate and severe pain. This difference in pain was statistically insignificant, but when compared to Group N (25 and 30%, respectively) it was statistically significant. Conclusion: Pretreatment with ramosetron 0.3 mg and lidocaine 40 mg are equally effective in preventing pain from propofol injection.http://www.joacp.org/article.asp?issn=0970-9185;year=2014;volume=30;issue=2;spage=213;epage=216;aulast=SinghInjectionlidocainepainpropofolramosetron |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dipali Singh Sathyanarayan Jagannath Shio Priye Shivaprakash Chandrashekar Kadli Durgaprasad Reddy |
spellingShingle |
Dipali Singh Sathyanarayan Jagannath Shio Priye Shivaprakash Chandrashekar Kadli Durgaprasad Reddy Prevention of propofol injection pain: Comparison between lidocaine and ramosetron Journal of Anaesthesiology Clinical Pharmacology Injection lidocaine pain propofol ramosetron |
author_facet |
Dipali Singh Sathyanarayan Jagannath Shio Priye Shivaprakash Chandrashekar Kadli Durgaprasad Reddy |
author_sort |
Dipali Singh |
title |
Prevention of propofol injection pain: Comparison between lidocaine and ramosetron |
title_short |
Prevention of propofol injection pain: Comparison between lidocaine and ramosetron |
title_full |
Prevention of propofol injection pain: Comparison between lidocaine and ramosetron |
title_fullStr |
Prevention of propofol injection pain: Comparison between lidocaine and ramosetron |
title_full_unstemmed |
Prevention of propofol injection pain: Comparison between lidocaine and ramosetron |
title_sort |
prevention of propofol injection pain: comparison between lidocaine and ramosetron |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Anaesthesiology Clinical Pharmacology |
issn |
0970-9185 |
publishDate |
2014-01-01 |
description |
Background: Propofol causes a high incidence of pain during intravenous (IV) injection. The aim of this randomized, placebo-controlled, double-blinded study was to determine whether pre-treatment with IV ramosetron, used for prophylaxis of postoperative nausea and vomiting (PONV), would reduce propofol-induced pain as an equivalent to lidocaine.
Materials and Methods: Hundred and twenty American Society of Anesthesiologists grade (ASA) I and II patients were randomly assigned into three groups (40 in each). Group N received 2 ml of 0.9% saline, Group L received 2 ml of lidocaine, and Group R received 2 ml of ramosetron. Mid forearm was occluded manually before injection and released after 1 min and then propofol was injected over 5 s. Patients were observed and questioned 15 s later if they had pain in the arm and pain was scored on a four-point scale: 0 = no pain, 1 = mild pain, 2 = moderate pain, and 3 = severe pain. Unpaired Student′s t-test and chi-square test/Fisher′ exact test were used to analyze results.
Results: The incidence of pain in groups N, L, and R were 65, 35, and 30%, respectively. Pain was reduced significantly in the groups L and R (P < 0.05). Two patients each in Groups L and R (5% each) had moderate and severe pain. This difference in pain was statistically insignificant, but when compared to Group N (25 and 30%, respectively) it was statistically significant.
Conclusion: Pretreatment with ramosetron 0.3 mg and lidocaine 40 mg are equally effective in preventing pain from propofol injection. |
topic |
Injection lidocaine pain propofol ramosetron |
url |
http://www.joacp.org/article.asp?issn=0970-9185;year=2014;volume=30;issue=2;spage=213;epage=216;aulast=Singh |
work_keys_str_mv |
AT dipalisingh preventionofpropofolinjectionpaincomparisonbetweenlidocaineandramosetron AT sathyanarayanjagannath preventionofpropofolinjectionpaincomparisonbetweenlidocaineandramosetron AT shiopriye preventionofpropofolinjectionpaincomparisonbetweenlidocaineandramosetron AT shivaprakash preventionofpropofolinjectionpaincomparisonbetweenlidocaineandramosetron AT chandrashekarkadli preventionofpropofolinjectionpaincomparisonbetweenlidocaineandramosetron AT durgaprasadreddy preventionofpropofolinjectionpaincomparisonbetweenlidocaineandramosetron |
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