Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model

Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model

Tumour-associated neutrophils (TANs) can support tumour growth by suppressing cytotoxic lymphocytes. AT-RvD1 is an eicosanoid that can antagonise neutrophil trafficking instigated by ALX/FPR2 ligands such as serum amyloid A (SAA). We aimed to establish whether SAA and ALOX5 expression associates wit...

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Bibliographic Details
Main Authors: Amanda Vannitamby, Mohamed I. Saad, Christian Aloe, Hao Wang, Beena Kumar, Ross Vlahos, Stavros Selemidis, Louis Irving, Daniel Steinfort, Brendan J. Jenkins, Steven Bozinovski
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
lung cancer
adenocarcinoma
neutrophils
resolution
inflammation
ALOX5
Online Access:https://www.mdpi.com/2072-6694/13/13/3224

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