Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights

Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights

DNA glycosylases are emerging as relevant pharmacological targets in inflammation, cancer and neurodegenerative diseases. Consequently, the search for inhibitors of these enzymes has become a very active research field. As a continuation of previous work that showed that 2-thioxanthine (2TX) is an i...

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Bibliographic Details
Main Authors: Charlotte Rieux, Stéphane Goffinont, Franck Coste, Zahira Tber, Julien Cros, Vincent Roy, Martine Guérin, Virginie Gaudon, Stéphane Bourg, Artur Biela, Vincent Aucagne, Luigi Agrofoglio, Norbert Garnier, Bertrand Castaing
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
ber
dna glycosylase
fpg/nei
hneil1
disulfide
cyclophane
dna repair inhibitors
zinc finger oxidation
Online Access:https://www.mdpi.com/1422-0067/21/6/2058

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https://www.mdpi.com/1422-0067/21/6/2058

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