Clinical and epidemiological factors associated with methicillin resistance in community-onset invasive Staphylococcus aureus infections: prospective multicenter cross-sectional study in Korea.
Successful empirical therapy of Staphylococcus aureus infections requires the ability to predict methicillin resistance. Our aim was to identify predictors of methicillin resistance in community-onset (CO) invasive S. aureus infections. Sixteen hospitals across Korea participated in this study from...
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doaj-200d3cb59b7e48ceb9ca2f685a70d48f2020-11-25T02:33:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11412710.1371/journal.pone.0114127Clinical and epidemiological factors associated with methicillin resistance in community-onset invasive Staphylococcus aureus infections: prospective multicenter cross-sectional study in Korea.Eu Suk KimHong Bin KimGayeon KimKye-Hyung KimKyung-Hwa ParkShinwon LeeYoung Hwa ChoiJongyoun YiChung Jong KimKyoung-Ho SongPyoeng Gyun ChoeNam-Joong KimYeong-Seon LeeMyoung-Don OhKorea INfectious Diseases (KIND) study groupSuccessful empirical therapy of Staphylococcus aureus infections requires the ability to predict methicillin resistance. Our aim was to identify predictors of methicillin resistance in community-onset (CO) invasive S. aureus infections. Sixteen hospitals across Korea participated in this study from May to December 2012. We prospectively included cases of S. aureus infection in which S. aureus was isolated from sterile clinical specimens ≤ 72 hours after hospitalization. Clinical and epidemiological data were gathered and compared in methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) cases. Community-associated (CA) infections were defined as in previous studies. In total, there were 786 cases of community-onset S. aureus infection, 102 (13.0%) of which were CA-MRSA. In addition to known risk factors, exposure to 3rd generation cephalosporins in the past 6 months [odds ratio (OR), 1.922; 95% confidence interval (CI), 1.176-3.142] and close contact with chronically ill patients in the past month (OR, 2.647; 95% CI, 1.189-5.891) were independent risk factors for MRSA infection. However, no clinical predictors of CA-MRSA were identified. Methicillin resistance, CO infection, and appropriateness of empirical antibiotics were not significantly related to 30-day mortality. MRSA infection should be suspected in patients recently exposed to 3rd generation cephalosporins or chronically-ill patients. There were no reliable predictors of CA-MRSA infection, and mortality was not affected by methicillin resistance.http://europepmc.org/articles/PMC4259386?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eu Suk Kim Hong Bin Kim Gayeon Kim Kye-Hyung Kim Kyung-Hwa Park Shinwon Lee Young Hwa Choi Jongyoun Yi Chung Jong Kim Kyoung-Ho Song Pyoeng Gyun Choe Nam-Joong Kim Yeong-Seon Lee Myoung-Don Oh Korea INfectious Diseases (KIND) study group |
spellingShingle |
Eu Suk Kim Hong Bin Kim Gayeon Kim Kye-Hyung Kim Kyung-Hwa Park Shinwon Lee Young Hwa Choi Jongyoun Yi Chung Jong Kim Kyoung-Ho Song Pyoeng Gyun Choe Nam-Joong Kim Yeong-Seon Lee Myoung-Don Oh Korea INfectious Diseases (KIND) study group Clinical and epidemiological factors associated with methicillin resistance in community-onset invasive Staphylococcus aureus infections: prospective multicenter cross-sectional study in Korea. PLoS ONE |
author_facet |
Eu Suk Kim Hong Bin Kim Gayeon Kim Kye-Hyung Kim Kyung-Hwa Park Shinwon Lee Young Hwa Choi Jongyoun Yi Chung Jong Kim Kyoung-Ho Song Pyoeng Gyun Choe Nam-Joong Kim Yeong-Seon Lee Myoung-Don Oh Korea INfectious Diseases (KIND) study group |
author_sort |
Eu Suk Kim |
title |
Clinical and epidemiological factors associated with methicillin resistance in community-onset invasive Staphylococcus aureus infections: prospective multicenter cross-sectional study in Korea. |
title_short |
Clinical and epidemiological factors associated with methicillin resistance in community-onset invasive Staphylococcus aureus infections: prospective multicenter cross-sectional study in Korea. |
title_full |
Clinical and epidemiological factors associated with methicillin resistance in community-onset invasive Staphylococcus aureus infections: prospective multicenter cross-sectional study in Korea. |
title_fullStr |
Clinical and epidemiological factors associated with methicillin resistance in community-onset invasive Staphylococcus aureus infections: prospective multicenter cross-sectional study in Korea. |
title_full_unstemmed |
Clinical and epidemiological factors associated with methicillin resistance in community-onset invasive Staphylococcus aureus infections: prospective multicenter cross-sectional study in Korea. |
title_sort |
clinical and epidemiological factors associated with methicillin resistance in community-onset invasive staphylococcus aureus infections: prospective multicenter cross-sectional study in korea. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Successful empirical therapy of Staphylococcus aureus infections requires the ability to predict methicillin resistance. Our aim was to identify predictors of methicillin resistance in community-onset (CO) invasive S. aureus infections. Sixteen hospitals across Korea participated in this study from May to December 2012. We prospectively included cases of S. aureus infection in which S. aureus was isolated from sterile clinical specimens ≤ 72 hours after hospitalization. Clinical and epidemiological data were gathered and compared in methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) cases. Community-associated (CA) infections were defined as in previous studies. In total, there were 786 cases of community-onset S. aureus infection, 102 (13.0%) of which were CA-MRSA. In addition to known risk factors, exposure to 3rd generation cephalosporins in the past 6 months [odds ratio (OR), 1.922; 95% confidence interval (CI), 1.176-3.142] and close contact with chronically ill patients in the past month (OR, 2.647; 95% CI, 1.189-5.891) were independent risk factors for MRSA infection. However, no clinical predictors of CA-MRSA were identified. Methicillin resistance, CO infection, and appropriateness of empirical antibiotics were not significantly related to 30-day mortality. MRSA infection should be suspected in patients recently exposed to 3rd generation cephalosporins or chronically-ill patients. There were no reliable predictors of CA-MRSA infection, and mortality was not affected by methicillin resistance. |
url |
http://europepmc.org/articles/PMC4259386?pdf=render |
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