Impact of percutaneous coronary intervention on patients with impaired baseline renal function
Background: Acute kidney injury (AKI) frequently co-prevails with acute coronary syndromes (ACS), which could improve post percutaneous coronary intervention (PCI). We sought to evaluate the impact of PCI on post-procedural renal function in patients with impaired baseline serum creatinine (Cr). Met...
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doaj-2012278585b34dbba485bd928facd0262020-11-25T04:07:03ZengElsevierIndian Heart Journal0019-48322020-09-01725356361Impact of percutaneous coronary intervention on patients with impaired baseline renal functionDeepti Yadav0Ankit Kumar Sahu1Roopali Khanna2Pravin K. Goel3Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, IndiaDepartment of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, IndiaDepartment of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, IndiaCorresponding author.; Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, IndiaBackground: Acute kidney injury (AKI) frequently co-prevails with acute coronary syndromes (ACS), which could improve post percutaneous coronary intervention (PCI). We sought to evaluate the impact of PCI on post-procedural renal function in patients with impaired baseline serum creatinine (Cr). Methods: Retrospective evaluation of 185 patients undergoing PCI with impaired basal serum Cr (≥ 1.5 mg/dl) was done, including 88 (47.5%) patients with recent ACS (≤2 weeks old) in group I and 97 (52.4%) patients in group II (stable angina or ACS >2 weeks old). Patients were classified into worsening or improving renal function based on a corresponding increase or decrease of ≥0.5 mg/dl (ΔCr) in serum Cr 24–48 h post PCI. ΔCr < 0.5 mg/dl was termed as no change. Results: A trend towards improving renal function was seen in the study cohort (mean serum Cr: 2.37 ± 1.25 mg/dl vs 2.28 ± 1.59 mg/dl); (p = 0.09) with decrease in group I from 2.28 ± 1.09 mg/dl to 2.12 ± 1.44 mg/dl (p = 0.03) and in group II from 2.45 ± 1.38 mg/dl to 2.43 ± 1.71 mg/dl (p = 0.81). Post PCI, worsening occurred in 20/185 (10.8%) patients in the total study cohort, 5/88 (5.6%) in group I and 15/97 (15.4%) in group II (p = 0.03). Improvement in serum Cr was seen in 49/185 (26.4%) in the total study cohort, 30/88 (34.1%) in group I and 19/97 (19.6%) patients in group II (p = 0.03). Conclusion: – Post PCI, only a small proportion of patients with impaired baseline creatinine showed worsening in renal function. Improved renal function was observed in at least one-third of the patients with recent ACS.http://www.sciencedirect.com/science/article/pii/S0019483220301516Percutaneous coronary interventionRenal dysfunctionContrast nephropathyAcute coronary syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Deepti Yadav Ankit Kumar Sahu Roopali Khanna Pravin K. Goel |
spellingShingle |
Deepti Yadav Ankit Kumar Sahu Roopali Khanna Pravin K. Goel Impact of percutaneous coronary intervention on patients with impaired baseline renal function Indian Heart Journal Percutaneous coronary intervention Renal dysfunction Contrast nephropathy Acute coronary syndrome |
author_facet |
Deepti Yadav Ankit Kumar Sahu Roopali Khanna Pravin K. Goel |
author_sort |
Deepti Yadav |
title |
Impact of percutaneous coronary intervention on patients with impaired baseline renal function |
title_short |
Impact of percutaneous coronary intervention on patients with impaired baseline renal function |
title_full |
Impact of percutaneous coronary intervention on patients with impaired baseline renal function |
title_fullStr |
Impact of percutaneous coronary intervention on patients with impaired baseline renal function |
title_full_unstemmed |
Impact of percutaneous coronary intervention on patients with impaired baseline renal function |
title_sort |
impact of percutaneous coronary intervention on patients with impaired baseline renal function |
publisher |
Elsevier |
series |
Indian Heart Journal |
issn |
0019-4832 |
publishDate |
2020-09-01 |
description |
Background: Acute kidney injury (AKI) frequently co-prevails with acute coronary syndromes (ACS), which could improve post percutaneous coronary intervention (PCI). We sought to evaluate the impact of PCI on post-procedural renal function in patients with impaired baseline serum creatinine (Cr). Methods: Retrospective evaluation of 185 patients undergoing PCI with impaired basal serum Cr (≥ 1.5 mg/dl) was done, including 88 (47.5%) patients with recent ACS (≤2 weeks old) in group I and 97 (52.4%) patients in group II (stable angina or ACS >2 weeks old). Patients were classified into worsening or improving renal function based on a corresponding increase or decrease of ≥0.5 mg/dl (ΔCr) in serum Cr 24–48 h post PCI. ΔCr < 0.5 mg/dl was termed as no change. Results: A trend towards improving renal function was seen in the study cohort (mean serum Cr: 2.37 ± 1.25 mg/dl vs 2.28 ± 1.59 mg/dl); (p = 0.09) with decrease in group I from 2.28 ± 1.09 mg/dl to 2.12 ± 1.44 mg/dl (p = 0.03) and in group II from 2.45 ± 1.38 mg/dl to 2.43 ± 1.71 mg/dl (p = 0.81). Post PCI, worsening occurred in 20/185 (10.8%) patients in the total study cohort, 5/88 (5.6%) in group I and 15/97 (15.4%) in group II (p = 0.03). Improvement in serum Cr was seen in 49/185 (26.4%) in the total study cohort, 30/88 (34.1%) in group I and 19/97 (19.6%) patients in group II (p = 0.03). Conclusion: – Post PCI, only a small proportion of patients with impaired baseline creatinine showed worsening in renal function. Improved renal function was observed in at least one-third of the patients with recent ACS. |
topic |
Percutaneous coronary intervention Renal dysfunction Contrast nephropathy Acute coronary syndrome |
url |
http://www.sciencedirect.com/science/article/pii/S0019483220301516 |
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