METHODS OF OBTAINING LIPOSOMES, USED AS DRUG DELIVERY SYSTEMS (REVIEW)
The article presents an overview of the main methods for producing liposomal medications, such as convectional and acoustic methods, high pressure method, detergent dissolution and removal method and the vapor method with phase inversion. The problems of hydrophobic technology of antioxidant pharmac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/419 |
| Summary: | The article presents an overview of the main methods for producing liposomal medications, such as convectional and acoustic methods, high pressure method, detergent dissolution and removal method and the vapor method with phase inversion. The problems of hydrophobic technology of antioxidant pharmaceuticals (low solubility and chemical stability of such drug) and the advantages of liposomes to deliver them are reported. It is established that the most promising technology of producing liposomes containing drugs with antioxidant effects is a thin film hydration method with further sonication. |
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| ISSN: | 2305-2066 2658-5049 |