Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic Research
Objectives: Discussions regarding who and how incidental findings (IFs) should be returned and the ethics behind returning IFs have increased dramatically over the years. However, information on the cost and benefits of returning IFs to patients remains scanty.Design: This study systematically revie...
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doaj-205db78f3a12401fa8dfcc352ea5984e2021-07-01T14:43:06ZengFrontiers Media S.A.Frontiers in Public Health2296-25652021-07-01910.3389/fpubh.2021.697381697381Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic ResearchMayara Fontes Marx0John E. Ataguba1Jantina de Vries2Ambroise Wonkam3Ambroise Wonkam4Department of Pathology, Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaHealth Economics Unit, School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaDepartment of Pathology, Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaDepartment of Pathology, Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaInstitute to Infectious Disease and Molecular Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaObjectives: Discussions regarding who and how incidental findings (IFs) should be returned and the ethics behind returning IFs have increased dramatically over the years. However, information on the cost and benefits of returning IFs to patients remains scanty.Design: This study systematically reviews the economic evaluation of returning IFs in genomic sequencing. We searched for published articles on the cost-effectiveness, cost-benefit, and cost-utility of IFs in Medline, Scopus, PubMed, and Google Scholar.Results: We found six published articles that met the eligibility criteria of this study. Two articles used cost analysis only, one used cost-benefit analysis only, two used both cost analysis and cost-effectiveness, and one used both cost-benefit analysis and cost-utility to describe the cost of returning IFs in genomic sequencing.Conclusion: While individuals value the IF results and are willing to pay for them, the cost of returning IFs depends on the primary health condition of the patient. Although patients were willing to pay, there was no clear evidence that returning IFs might be cost-effective. More rigorous economic evaluation studies of IFs are needed to determine whether or not the cost of returning IFs is beneficial to the patient.https://www.frontiersin.org/articles/10.3389/fpubh.2021.697381/fulleconomic evaluationgenetic researchsystematic reviewincidental (secondary) findingscosts |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mayara Fontes Marx John E. Ataguba Jantina de Vries Ambroise Wonkam Ambroise Wonkam |
spellingShingle |
Mayara Fontes Marx John E. Ataguba Jantina de Vries Ambroise Wonkam Ambroise Wonkam Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic Research Frontiers in Public Health economic evaluation genetic research systematic review incidental (secondary) findings costs |
author_facet |
Mayara Fontes Marx John E. Ataguba Jantina de Vries Ambroise Wonkam Ambroise Wonkam |
author_sort |
Mayara Fontes Marx |
title |
Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic Research |
title_short |
Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic Research |
title_full |
Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic Research |
title_fullStr |
Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic Research |
title_full_unstemmed |
Systematic Review of the Economic Evaluation of Returning Incidental Findings in Genomic Research |
title_sort |
systematic review of the economic evaluation of returning incidental findings in genomic research |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Public Health |
issn |
2296-2565 |
publishDate |
2021-07-01 |
description |
Objectives: Discussions regarding who and how incidental findings (IFs) should be returned and the ethics behind returning IFs have increased dramatically over the years. However, information on the cost and benefits of returning IFs to patients remains scanty.Design: This study systematically reviews the economic evaluation of returning IFs in genomic sequencing. We searched for published articles on the cost-effectiveness, cost-benefit, and cost-utility of IFs in Medline, Scopus, PubMed, and Google Scholar.Results: We found six published articles that met the eligibility criteria of this study. Two articles used cost analysis only, one used cost-benefit analysis only, two used both cost analysis and cost-effectiveness, and one used both cost-benefit analysis and cost-utility to describe the cost of returning IFs in genomic sequencing.Conclusion: While individuals value the IF results and are willing to pay for them, the cost of returning IFs depends on the primary health condition of the patient. Although patients were willing to pay, there was no clear evidence that returning IFs might be cost-effective. More rigorous economic evaluation studies of IFs are needed to determine whether or not the cost of returning IFs is beneficial to the patient. |
topic |
economic evaluation genetic research systematic review incidental (secondary) findings costs |
url |
https://www.frontiersin.org/articles/10.3389/fpubh.2021.697381/full |
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