Targeting autophagy potentiates the anti-tumor effect of PARP inhibitor in pediatric chronic myeloid leukemia

Targeting autophagy potentiates the anti-tumor effect of PARP inhibitor in pediatric chronic myeloid leukemia

Abstract Due to its potent cytotoxicity in BRCA-mutated tumors, synthetic lethality elicited by poly (ADP-ribose) polymerase (PARP) inhibitor gives renewed enthusiasm to researching and developing anti-cancer therapies. Chronic myeloid leukemia (CML) is a type of cancers that starts in certain blood...

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Bibliographic Details
Main Authors: Yuanyuan Liu, Hong Song, Huanqing Song, Xiaoxia Feng, Chuan Zhou, Zhifang Huo
Format: Article
Language:English
Published: SpringerOpen 2019-07-01
Series:AMB Express
Subjects:
Pediatric chronic myeloid leukemia
Talazoparib
Cytotoxicity
Autophagy
Online Access:http://link.springer.com/article/10.1186/s13568-019-0836-z

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http://link.springer.com/article/10.1186/s13568-019-0836-z

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