Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels

Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels

The host immune system offers a hostile environment with antimicrobials and reactive oxygen species (ROS) that are detrimental to bacterial pathogens, forcing them to adapt and evolve for survival. However, the contribution of oxidative stress to pathogen evolution remains elusive. Using an experime...

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Bibliographic Details
Main Authors: Song Lin Chua, Yichen Ding, Yang Liu, Zhao Cai, Jianuan Zhou, Sanjay Swarup, Daniela I. Drautz-Moses, Stephan Christoph Schuster, Staffan Kjelleberg, Michael Givskov, Liang Yang
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Open Biology
Subjects:
biofilms
c-di-gmp
rough small colony variants
reactive oxygen species
pseudomonas aeruginosa
adaptive evolution
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160162

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160162

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