Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.

Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.

The DEAD box helicase DDX3 assembles IPS-1 (also called Cardif, MAVS, or VISA) in non-infected human cells where minimal amounts of the RIG-I-like receptor (RLR) protein are expressed. DDX3 C-terminal regions directly bind the IPS-1 CARD-like domain as well as the N-terminal hepatitis C virus (HCV)...

Full description

Bibliographic Details
Main Authors: Hiroyuki Oshiumi, Masanori Ikeda, Misako Matsumoto, Ayako Watanabe, Osamu Takeuchi, Shizuo Akira, Nobuyuki Kato, Kunitada Shimotohno, Tsukasa Seya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2999533?pdf=render

Internet

http://europepmc.org/articles/PMC2999533?pdf=render

Similar Items