Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.

Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.

Immune evasion is now recognized as a key feature of cancer progression. In animal models, the activity of cytotoxic lymphocytes is suppressed in the tumour microenvironment by the immunosuppressive cytokine, Transforming Growth Factor (TGF)-β. Release from TGF-β-mediated inhibition restores anti-tu...

Full description

Bibliographic Details
Main Authors: Erica B Wilson, Jehan J El-Jawhari, Abbie L Neilson, Geoffrey D Hall, Alan A Melcher, Josephine L Meade, Graham P Cook
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21909397/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21909397/?tool=EBI

Similar Items