SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population.
BACKGROUND: Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy. A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain...
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doaj-21014b109d7f4662b142ee23abb649752020-11-25T02:51:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-01512e1579210.1371/journal.pone.0015792SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population.Yuan ZhangSu DuanXiaoping LinWei ZhangNa MengLiping ZhaoYan ZhaoDemin HanLuo ZhangBACKGROUND: Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy. A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) as a susceptibility locus influencing total serum IgE levels. The aim of this study was to investigate whether the polymorphisms in the FCER1A gene are associated with allergic rhinitis (AR) in a Han Chinese population. METHODOLOGY/PRINCIPAL FINDINGS: A population of 378 patients with AR and 288 healthy controls was studied. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE) measurement. A total of 16 single nucleotide polymorphisms (SNPs) in FCER1A were selected and individually genotyped. None of the SNPs in the FCER1A showed an association with AR. Similarly, the lack of association was also evident in subgroup analysis for the presence of different allergen sensitivities. None of the selected SNPs in FCER1A was associated with total IgE level. CONCLUSIONS: Although FCER1A presents itself as a good candidate for contributing to total serum IgE, this study failed to find an association between SNPs in the FCER1A gene region and IgE level or AR susceptibility.http://europepmc.org/articles/PMC3013135?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuan Zhang Su Duan Xiaoping Lin Wei Zhang Na Meng Liping Zhao Yan Zhao Demin Han Luo Zhang |
spellingShingle |
Yuan Zhang Su Duan Xiaoping Lin Wei Zhang Na Meng Liping Zhao Yan Zhao Demin Han Luo Zhang SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population. PLoS ONE |
author_facet |
Yuan Zhang Su Duan Xiaoping Lin Wei Zhang Na Meng Liping Zhao Yan Zhao Demin Han Luo Zhang |
author_sort |
Yuan Zhang |
title |
SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population. |
title_short |
SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population. |
title_full |
SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population. |
title_fullStr |
SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population. |
title_full_unstemmed |
SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population. |
title_sort |
snps in the fcer1a gene region show no association with allergic rhinitis in a han chinese population. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2010-01-01 |
description |
BACKGROUND: Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy. A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) as a susceptibility locus influencing total serum IgE levels. The aim of this study was to investigate whether the polymorphisms in the FCER1A gene are associated with allergic rhinitis (AR) in a Han Chinese population. METHODOLOGY/PRINCIPAL FINDINGS: A population of 378 patients with AR and 288 healthy controls was studied. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE) measurement. A total of 16 single nucleotide polymorphisms (SNPs) in FCER1A were selected and individually genotyped. None of the SNPs in the FCER1A showed an association with AR. Similarly, the lack of association was also evident in subgroup analysis for the presence of different allergen sensitivities. None of the selected SNPs in FCER1A was associated with total IgE level. CONCLUSIONS: Although FCER1A presents itself as a good candidate for contributing to total serum IgE, this study failed to find an association between SNPs in the FCER1A gene region and IgE level or AR susceptibility. |
url |
http://europepmc.org/articles/PMC3013135?pdf=render |
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