Clarithromycin Enhances the Antibacterial Activity and Wound Healing Capacity in Type 2 Diabetes Mellitus by Increasing LL-37 Load on Neutrophil Extracellular Traps

Clarithromycin Enhances the Antibacterial Activity and Wound Healing Capacity in Type 2 Diabetes Mellitus by Increasing LL-37 Load on Neutrophil Extracellular Traps

Background: Type 2 diabetes mellitus (T2D) is characterized by susceptibility to bacterial infections and impaired wound healing. Neutrophil extracellular traps (NETs) and the cathelicidin antimicrobial peptide LL-37 have been implicated both in defense against bacterial infections and in wound heal...

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Bibliographic Details
Main Authors: Athanasios Arampatzioglou, Dimitrios Papazoglou, Theocharis Konstantinidis, Akrivi Chrysanthopoulou, Alexandros Mitsios, Iliana Angelidou, Ioanna Maroulakou, Konstantinos Ritis, Panagiotis Skendros
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
type 2 diabetes mellitus
neutrophil extracellular traps
LL-37
clarithromycin
diabetic infections
wound healing
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02064/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02064/full

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