The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis—Dysregulation by the Liver
Accumulation of hepatic triacylglycerol (TG) is associated with obesity and metabolic syndrome, which are important pathogenic factors in the development of type 2 diabetes. In this narrative review, we summarize the effects of hepatic TG accumulation on hepatic glucose and insulin metabolism and th...
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/3/390 |
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doaj-2131c346d20a4f268579eddf26d784362021-01-21T00:05:24ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-011039039010.3390/jcm10030390The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis—Dysregulation by the LiverAmalie London0Anne-Marie Lundsgaard1Bente Kiens2Kirstine Nyvold Bojsen-Møller3Department of Endocrinology, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, 2650 Hvidovre, DenmarkSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen, DenmarkSection of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen, DenmarkDepartment of Endocrinology, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, 2650 Hvidovre, DenmarkAccumulation of hepatic triacylglycerol (TG) is associated with obesity and metabolic syndrome, which are important pathogenic factors in the development of type 2 diabetes. In this narrative review, we summarize the effects of hepatic TG accumulation on hepatic glucose and insulin metabolism and the underlying molecular regulation in order to highlight the importance of hepatic TG accumulation for whole-body glucose metabolism. We find that liver fat accumulation is closely linked to impaired insulin-mediated suppression of hepatic glucose production and reduced hepatic insulin clearance. The resulting systemic hyperinsulinemia has a major impact on whole-body glucose metabolism and may be an important pathogenic step in the development of type 2 diabetes.https://www.mdpi.com/2077-0383/10/3/390non-alcoholic fatty liver disease (NAFLD)glucose metabolisminsulin resistancehepatic glucose productionhyperinsulinemic-euglycemic clampproton MR spectroscopy |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Amalie London Anne-Marie Lundsgaard Bente Kiens Kirstine Nyvold Bojsen-Møller |
| spellingShingle |
Amalie London Anne-Marie Lundsgaard Bente Kiens Kirstine Nyvold Bojsen-Møller The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis—Dysregulation by the Liver Journal of Clinical Medicine non-alcoholic fatty liver disease (NAFLD) glucose metabolism insulin resistance hepatic glucose production hyperinsulinemic-euglycemic clamp proton MR spectroscopy |
| author_facet |
Amalie London Anne-Marie Lundsgaard Bente Kiens Kirstine Nyvold Bojsen-Møller |
| author_sort |
Amalie London |
| title |
The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis—Dysregulation by the Liver |
| title_short |
The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis—Dysregulation by the Liver |
| title_full |
The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis—Dysregulation by the Liver |
| title_fullStr |
The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis—Dysregulation by the Liver |
| title_full_unstemmed |
The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis—Dysregulation by the Liver |
| title_sort |
role of hepatic fat accumulation in glucose and insulin homeostasis—dysregulation by the liver |
| publisher |
MDPI AG |
| series |
Journal of Clinical Medicine |
| issn |
2077-0383 |
| publishDate |
2021-01-01 |
| description |
Accumulation of hepatic triacylglycerol (TG) is associated with obesity and metabolic syndrome, which are important pathogenic factors in the development of type 2 diabetes. In this narrative review, we summarize the effects of hepatic TG accumulation on hepatic glucose and insulin metabolism and the underlying molecular regulation in order to highlight the importance of hepatic TG accumulation for whole-body glucose metabolism. We find that liver fat accumulation is closely linked to impaired insulin-mediated suppression of hepatic glucose production and reduced hepatic insulin clearance. The resulting systemic hyperinsulinemia has a major impact on whole-body glucose metabolism and may be an important pathogenic step in the development of type 2 diabetes. |
| topic |
non-alcoholic fatty liver disease (NAFLD) glucose metabolism insulin resistance hepatic glucose production hyperinsulinemic-euglycemic clamp proton MR spectroscopy |
| url |
https://www.mdpi.com/2077-0383/10/3/390 |
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