[18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis

[18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis

Abstract Background The cystine/glutamate antiporter (xc-) has been implicated in several neurological disorders and, specifically, in multiple sclerosis (MS) as a mediator of glutamate excitotoxicity and proinflammatory immune responses. We aimed to evaluate an xc-specific positron emission tomogra...

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Bibliographic Details
Main Authors: Aileen Hoehne, Michelle L. James, Israt S. Alam, John A. Ronald, Bernadette Schneider, Aloma D’Souza, Timothy H. Witney, Lauren E. Andrews, Haley C. Cropper, Deepak Behera, Gayatri Gowrishankar, Zhaoqing Ding, Tony Wyss-Coray, Frederick T. Chin, Sandip Biswal, Sanjiv S. Gambhir
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Neuroinflammation
Subjects:
FSPG
PET
Multiple sclerosis
EAE mice
Xc-
Online Access:http://link.springer.com/article/10.1186/s12974-018-1080-1

Internet

http://link.springer.com/article/10.1186/s12974-018-1080-1

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