Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

When a T cell and an antigen-presenting cell form an immunological synapse, rapid dynein-driven translocation of the centrosome toward the contact site leads to reorganization of microtubules and associated organelles. Currently, little is known about how the regulation of microtubule dynamics contr...

Full description

Bibliographic Details
Main Authors: Peter Jan Hooikaas, Hugo GJ Damstra, Oane J Gros, Wilhelmina E van Riel, Maud Martin, Yesper TH Smits, Jorg van Loosdregt, Lukas C Kapitein, Florian Berger, Anna Akhmanova
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
microtubule
kinesin
centrosome
immunological synapse
polarization
modeling
Online Access:https://elifesciences.org/articles/62876

Internet

https://elifesciences.org/articles/62876

Similar Items