Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats

Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats

We have characterized a lean type 2 diabetic rat model by gestational low protein programming. We aimed to identify if the regulation of hepatic glucose production (HGP) via gluconeogenesis and glycogenolysis is affected and if there are any sex differences. Fasting (6–7 months old) type 2 diabetic...

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Bibliographic Details
Main Authors: Chellakkan S. Blesson, Amy Schutt, Shaji Chacko, Juan C. Marini, Pretty Rose Mathew, Daren Tanchico, Meena Balakrishnan, Chandra Yallampalli
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Endocrinology
Subjects:
developmental programing
glucose intolerance
insulin resistance
glucose production
gluconeogenesis
glycogenolysis
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00538/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00538/full

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