Genetically Regulated Bilirubin and Risk of Non-alcoholic Fatty Liver Disease: A Mendelian Randomization Study

Genetically Regulated Bilirubin and Risk of Non-alcoholic Fatty Liver Disease: A Mendelian Randomization Study

Mildly elevated serum bilirubin levels were reported to be associated with decreased risk of non-alcoholic fatty liver disease (NAFLD). Whether this is a causal relationship remains unclear. We tested the hypothesis that genetically elevated plasma bilirubin levels are causally related to reduce ris...

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Bibliographic Details
Main Authors: Lei Luo, Ping An, Xinyong Jia, Xiaobian Yue, Sujun Zheng, Shuang Liu, Yu Chen, Wei An, Cheryl A. Winkler, Zhongping Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Genetics
Subjects:
bilirubin
NAFLD
variant
UGT1A1
mendelian randomization
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00662/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00662/full

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