Utility of plasma cell‐free DNA in metastatic castration‐resistant prostate cancer
Introduction Cell‐free DNA is suggested as a prognostic biomarker in metastatic castration‐resistant prostate cancer. However, it remains unknown which parameter of cell‐free DNA is correlated with the progression and prognosis of metastatic castration‐resistant prostate cancer. Case presentation A...
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doaj-2246fa5a797547139ea50004ce11ae882020-11-25T03:46:38ZengWileyIJU Case Reports2577-171X2020-07-013414114410.1002/iju5.12172Utility of plasma cell‐free DNA in metastatic castration‐resistant prostate cancerItsuto Hamano0Shingo Hatakeyama1Tomoko Hamaya2Kyo Togashi3Teppei Okamoto4Hayato Yamamoto5Tohru Yoneyama6Takahiro Yoneyama7Yasuhiro Hashimoto8Chikara Ohyama9Departments of Department of Urology Hirosaki University Graduate School of Medicine Hirosaki JapanDepartment of Advanced Blood Purification Therapy Hirosaki University Graduate School of Medicine Hirosaki JapanDepartments of Department of Urology Hirosaki University Graduate School of Medicine Hirosaki JapanDepartments of Department of Urology Hirosaki University Graduate School of Medicine Hirosaki JapanDepartments of Department of Urology Hirosaki University Graduate School of Medicine Hirosaki JapanDepartments of Department of Urology Hirosaki University Graduate School of Medicine Hirosaki JapanDepartment of Advanced Transplant and Regenerative Medicine Hirosaki University Graduate School of Medicine Hirosaki JapanDepartment of Advanced Transplant and Regenerative Medicine Hirosaki University Graduate School of Medicine Hirosaki JapanDepartments of Department of Urology Hirosaki University Graduate School of Medicine Hirosaki JapanDepartments of Department of Urology Hirosaki University Graduate School of Medicine Hirosaki JapanIntroduction Cell‐free DNA is suggested as a prognostic biomarker in metastatic castration‐resistant prostate cancer. However, it remains unknown which parameter of cell‐free DNA is correlated with the progression and prognosis of metastatic castration‐resistant prostate cancer. Case presentation A 75‐year‐old man with newly diagnosed prostate cancer (serum prostate‐specific antigen 4891 ng/mL, Gleason score 4 + 5 = 9, cT3bN1M1) was referred to our department. He first received sequential hormonal therapies and was consequently diagnosed metastatic castration‐resistant prostate cancer 64 months after initial treatment. He underwent serial examinations of plasma cell‐free DNA, including concentration, androgen receptor amplification, TP53 point mutation, and PTEN loss. Only the cell‐free DNA concentration increased along with disease progression and declined after the administration of abiraterone and enzalutamide. Conclusion This case presented that cell‐free DNA concentration was possibly correlated with response to castration‐resistant prostate cancer treatment and disease progression. Cell‐free DNA concentration was proposed as a potential prognostic biomarker of metastatic castration‐resistant prostate cancer.https://doi.org/10.1002/iju5.12172androgen receptorbiomarkercastration‐resistant prostate cancercell‐free DNAconcentration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Itsuto Hamano Shingo Hatakeyama Tomoko Hamaya Kyo Togashi Teppei Okamoto Hayato Yamamoto Tohru Yoneyama Takahiro Yoneyama Yasuhiro Hashimoto Chikara Ohyama |
spellingShingle |
Itsuto Hamano Shingo Hatakeyama Tomoko Hamaya Kyo Togashi Teppei Okamoto Hayato Yamamoto Tohru Yoneyama Takahiro Yoneyama Yasuhiro Hashimoto Chikara Ohyama Utility of plasma cell‐free DNA in metastatic castration‐resistant prostate cancer IJU Case Reports androgen receptor biomarker castration‐resistant prostate cancer cell‐free DNA concentration |
author_facet |
Itsuto Hamano Shingo Hatakeyama Tomoko Hamaya Kyo Togashi Teppei Okamoto Hayato Yamamoto Tohru Yoneyama Takahiro Yoneyama Yasuhiro Hashimoto Chikara Ohyama |
author_sort |
Itsuto Hamano |
title |
Utility of plasma cell‐free DNA in metastatic castration‐resistant prostate cancer |
title_short |
Utility of plasma cell‐free DNA in metastatic castration‐resistant prostate cancer |
title_full |
Utility of plasma cell‐free DNA in metastatic castration‐resistant prostate cancer |
title_fullStr |
Utility of plasma cell‐free DNA in metastatic castration‐resistant prostate cancer |
title_full_unstemmed |
Utility of plasma cell‐free DNA in metastatic castration‐resistant prostate cancer |
title_sort |
utility of plasma cell‐free dna in metastatic castration‐resistant prostate cancer |
publisher |
Wiley |
series |
IJU Case Reports |
issn |
2577-171X |
publishDate |
2020-07-01 |
description |
Introduction Cell‐free DNA is suggested as a prognostic biomarker in metastatic castration‐resistant prostate cancer. However, it remains unknown which parameter of cell‐free DNA is correlated with the progression and prognosis of metastatic castration‐resistant prostate cancer. Case presentation A 75‐year‐old man with newly diagnosed prostate cancer (serum prostate‐specific antigen 4891 ng/mL, Gleason score 4 + 5 = 9, cT3bN1M1) was referred to our department. He first received sequential hormonal therapies and was consequently diagnosed metastatic castration‐resistant prostate cancer 64 months after initial treatment. He underwent serial examinations of plasma cell‐free DNA, including concentration, androgen receptor amplification, TP53 point mutation, and PTEN loss. Only the cell‐free DNA concentration increased along with disease progression and declined after the administration of abiraterone and enzalutamide. Conclusion This case presented that cell‐free DNA concentration was possibly correlated with response to castration‐resistant prostate cancer treatment and disease progression. Cell‐free DNA concentration was proposed as a potential prognostic biomarker of metastatic castration‐resistant prostate cancer. |
topic |
androgen receptor biomarker castration‐resistant prostate cancer cell‐free DNA concentration |
url |
https://doi.org/10.1002/iju5.12172 |
work_keys_str_mv |
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