Polyfunctional Fc Dependent Activity of Antibodies to Native Trimeric Envelope in HIV Elite Controllers

Polyfunctional Fc Dependent Activity of Antibodies to Native Trimeric Envelope in HIV Elite Controllers

Antibody dependent (AD) functions such as AD cellular cytotoxicity (ADCC) were associated with lower viral load (VL) in untreated HIV progressors and protection from HIV infection in the modestly protective RV144 HIV vaccine trial. Target cells used to measure ADCC, AD complement deposition (ADCD),...

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Bibliographic Details
Main Authors: Sanket Kant, Ningyu Zhang, Alexandre Barbé, Jean-Pierre Routy, Cécile Tremblay, Réjean Thomas, Jason Szabo, Pierre Côté, Benoit Trottier, Roger LeBlanc, Danielle Rouleau, Marianne Harris, Franck P. Dupuy, Nicole F. Bernard
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
HIV
antibody dependent functions
ADCC
HIV reservoir
Elite controllers
HIV+ plasma
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.583820/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.583820/full

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