Pharmacokinetics of black tea-derived phenolic acids in plasma
Little is known about the pharmacokinetics of black tea metabolically-derived phenolic acids (PAs). This knowledge is required to better understand their putative role in human health. Plasma concentrations of 18 PAs were measured after intake of 2650 mg black tea extract, combined with a 50 mg dose...
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doaj-2267bd437101453a98d2fcba9959dd7d2021-04-29T04:44:48ZengElsevierJournal of Functional Foods1756-46462015-08-0117667675Pharmacokinetics of black tea-derived phenolic acids in plasmaPieter C. van der Pijl0Martin Foltz1Natalie D. Glube2Sonja Peters3Guus S.M.J.E. Duchateau4Unilever Research and Development Vlaardingen, 3133 AT, Vlaardingen, The Netherlands; Corresponding author. Unilever Research and Development Vlaardingen, 3133 AT, Vlaardingen, The Netherlands. Tel.: +31 10 460 54 54; fax: +31 10 460 59 93.Unilever Research and Development Vlaardingen, 3133 AT, Vlaardingen, The NetherlandsUnilever Research and Development Vlaardingen, 3133 AT, Vlaardingen, The Netherlands; BASF SE, Human Nutrition Europe, 68623 Lampertheim, GermanyUnilever Research and Development Vlaardingen, 3133 AT, Vlaardingen, The NetherlandsUnilever Research and Development Vlaardingen, 3133 AT, Vlaardingen, The NetherlandsLittle is known about the pharmacokinetics of black tea metabolically-derived phenolic acids (PAs). This knowledge is required to better understand their putative role in human health. Plasma concentrations of 18 PAs were measured after intake of 2650 mg black tea extract, combined with a 50 mg dose of three selected mass-labelled PAs. Levels of 15 PAs remained constant at low-µmol/L range. In contrast, those of 4–O–methylgallic acid, gallic acid, and hippuric acid peaked at up to 6.5 µmol/L after 1.3 to 8.8 h. Absorption and elimination half-lives of the mass-labelled PAs ranged from 0.35 to 1.24 h. A wide range of PAs were accurately quantified in plasma after black tea extract intake. Their mostly constant plasma concentrations may be due to slow formation and fast elimination, as indicated by the fast pharmacokinetics of mass-labelled PAs. These findings support the physiological significance of identified black tea metabolites.http://www.sciencedirect.com/science/article/pii/S1756464615003047PharmacokineticsPhenolic acidPolyphenolTeaVascular health |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pieter C. van der Pijl Martin Foltz Natalie D. Glube Sonja Peters Guus S.M.J.E. Duchateau |
spellingShingle |
Pieter C. van der Pijl Martin Foltz Natalie D. Glube Sonja Peters Guus S.M.J.E. Duchateau Pharmacokinetics of black tea-derived phenolic acids in plasma Journal of Functional Foods Pharmacokinetics Phenolic acid Polyphenol Tea Vascular health |
author_facet |
Pieter C. van der Pijl Martin Foltz Natalie D. Glube Sonja Peters Guus S.M.J.E. Duchateau |
author_sort |
Pieter C. van der Pijl |
title |
Pharmacokinetics of black tea-derived phenolic acids in plasma |
title_short |
Pharmacokinetics of black tea-derived phenolic acids in plasma |
title_full |
Pharmacokinetics of black tea-derived phenolic acids in plasma |
title_fullStr |
Pharmacokinetics of black tea-derived phenolic acids in plasma |
title_full_unstemmed |
Pharmacokinetics of black tea-derived phenolic acids in plasma |
title_sort |
pharmacokinetics of black tea-derived phenolic acids in plasma |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2015-08-01 |
description |
Little is known about the pharmacokinetics of black tea metabolically-derived phenolic acids (PAs). This knowledge is required to better understand their putative role in human health. Plasma concentrations of 18 PAs were measured after intake of 2650 mg black tea extract, combined with a 50 mg dose of three selected mass-labelled PAs. Levels of 15 PAs remained constant at low-µmol/L range. In contrast, those of 4–O–methylgallic acid, gallic acid, and hippuric acid peaked at up to 6.5 µmol/L after 1.3 to 8.8 h. Absorption and elimination half-lives of the mass-labelled PAs ranged from 0.35 to 1.24 h. A wide range of PAs were accurately quantified in plasma after black tea extract intake. Their mostly constant plasma concentrations may be due to slow formation and fast elimination, as indicated by the fast pharmacokinetics of mass-labelled PAs. These findings support the physiological significance of identified black tea metabolites. |
topic |
Pharmacokinetics Phenolic acid Polyphenol Tea Vascular health |
url |
http://www.sciencedirect.com/science/article/pii/S1756464615003047 |
work_keys_str_mv |
AT pietercvanderpijl pharmacokineticsofblackteaderivedphenolicacidsinplasma AT martinfoltz pharmacokineticsofblackteaderivedphenolicacidsinplasma AT nataliedglube pharmacokineticsofblackteaderivedphenolicacidsinplasma AT sonjapeters pharmacokineticsofblackteaderivedphenolicacidsinplasma AT guussmjeduchateau pharmacokineticsofblackteaderivedphenolicacidsinplasma |
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1721501693029384192 |