Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region

Germline POLE and POLD1 proofreading domain mutations in endometrial carcinoma from Middle Eastern region

Abstract Background Endometrial carcinoma (EC) accounts for 5.8% of all cancers in Saudi females. Although most ECs are sporadic, 2–5% tend to be familial, being associated with Lynch syndrome and Cowden syndrome. In this study, we attempted to uncover the frequency, spectrum and phenotype of germli...

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Bibliographic Details
Main Authors: Abdul K. Siraj, Sandeep Kumar Parvathareddy, Rong Bu, Kaleem Iqbal, Sarah Siraj, Tariq Masoodi, Rica Micaela Concepcion, Laila Omar Ghazwani, Ismail AlBadawi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Cancer Cell International
Subjects:
Endometrial carcinoma
POLE
POLD1
Proofreading domains
Online Access:https://doi.org/10.1186/s12935-019-1058-9

Internet

https://doi.org/10.1186/s12935-019-1058-9

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