Crizotinib-induced immunogenic cell death in non-small cell lung cancer
Certain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell death and can potentiate the efficacy of immune chec...
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| Format: | Article |
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Nature Publishing Group
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09415-3 |
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doaj-228ee56caf814e7fbcca341ed093aaed2021-05-11T12:22:27ZengNature Publishing GroupNature Communications2041-17232019-04-0110111710.1038/s41467-019-09415-3Crizotinib-induced immunogenic cell death in non-small cell lung cancerPeng Liu0Liwei Zhao1Jonathan Pol2Sarah Levesque3Adriana Petrazzuolo4Christina Pfirschke5Camilla Engblom6Steffen Rickelt7Takahiro Yamazaki8Kristina Iribarren9Laura Senovilla10Lucillia Bezu11Erika Vacchelli12Valentina Sica13Andréa Melis14Tiffany Martin15Lin Xia16Heng Yang17Qingqing Li18Jinfeng Chen19Sylvère Durand20Fanny Aprahamian21Deborah Lefevre22Sophie Broutin23Angelo Paci24Amaury Bongers25Veronique Minard-Colin26Eric Tartour27Laurence Zitvogel28Lionel Apetoh29Yuting Ma30Mikael J. Pittet31Oliver Kepp32Guido Kroemer33Faculty of Medicine, University of Paris SudFaculty of Medicine, University of Paris SudCell Biology and Metabolomics Platforms, Gustave Roussy Cancer CampusFaculty of Medicine, University of Paris SudFaculty of Medicine, University of Paris SudCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical SchoolCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical SchoolKoch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyDepartment of Radiation Oncology, Weill Cornell Medical CollegeCell Biology and Metabolomics Platforms, Gustave Roussy Cancer CampusCell Biology and Metabolomics Platforms, Gustave Roussy Cancer CampusFaculty of Medicine, University of Paris SudCell Biology and Metabolomics Platforms, Gustave Roussy Cancer CampusCell Biology and Metabolomics Platforms, Gustave Roussy Cancer CampusCentre de Recherche INSERM LNC-Centre de Recherche INSERM LNC-Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCell Biology and Metabolomics Platforms, Gustave Roussy Cancer CampusCell Biology and Metabolomics Platforms, Gustave Roussy Cancer CampusCell Biology and Metabolomics Platforms, Gustave Roussy Cancer CampusDepartment of Pharmacology, Institut Gustave RoussyDepartment of Pharmacology, Institut Gustave RoussyDepartment of Pharmacology, Institut Gustave RoussyInstitut de Cancérologie, Gustave Roussy Cancer Campus (GRCC)INSERM U970, Université Paris Descartes Sorbonne Paris-CitéFaculty of Medicine, University of Paris SudCentre de Recherche INSERM LNC-Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical SchoolFaculty of Medicine, University of Paris SudCell Biology and Metabolomics Platforms, Gustave Roussy Cancer CampusCertain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell death and can potentiate the efficacy of immune checkpoint blockade.https://doi.org/10.1038/s41467-019-09415-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Peng Liu Liwei Zhao Jonathan Pol Sarah Levesque Adriana Petrazzuolo Christina Pfirschke Camilla Engblom Steffen Rickelt Takahiro Yamazaki Kristina Iribarren Laura Senovilla Lucillia Bezu Erika Vacchelli Valentina Sica Andréa Melis Tiffany Martin Lin Xia Heng Yang Qingqing Li Jinfeng Chen Sylvère Durand Fanny Aprahamian Deborah Lefevre Sophie Broutin Angelo Paci Amaury Bongers Veronique Minard-Colin Eric Tartour Laurence Zitvogel Lionel Apetoh Yuting Ma Mikael J. Pittet Oliver Kepp Guido Kroemer |
| spellingShingle |
Peng Liu Liwei Zhao Jonathan Pol Sarah Levesque Adriana Petrazzuolo Christina Pfirschke Camilla Engblom Steffen Rickelt Takahiro Yamazaki Kristina Iribarren Laura Senovilla Lucillia Bezu Erika Vacchelli Valentina Sica Andréa Melis Tiffany Martin Lin Xia Heng Yang Qingqing Li Jinfeng Chen Sylvère Durand Fanny Aprahamian Deborah Lefevre Sophie Broutin Angelo Paci Amaury Bongers Veronique Minard-Colin Eric Tartour Laurence Zitvogel Lionel Apetoh Yuting Ma Mikael J. Pittet Oliver Kepp Guido Kroemer Crizotinib-induced immunogenic cell death in non-small cell lung cancer Nature Communications |
| author_facet |
Peng Liu Liwei Zhao Jonathan Pol Sarah Levesque Adriana Petrazzuolo Christina Pfirschke Camilla Engblom Steffen Rickelt Takahiro Yamazaki Kristina Iribarren Laura Senovilla Lucillia Bezu Erika Vacchelli Valentina Sica Andréa Melis Tiffany Martin Lin Xia Heng Yang Qingqing Li Jinfeng Chen Sylvère Durand Fanny Aprahamian Deborah Lefevre Sophie Broutin Angelo Paci Amaury Bongers Veronique Minard-Colin Eric Tartour Laurence Zitvogel Lionel Apetoh Yuting Ma Mikael J. Pittet Oliver Kepp Guido Kroemer |
| author_sort |
Peng Liu |
| title |
Crizotinib-induced immunogenic cell death in non-small cell lung cancer |
| title_short |
Crizotinib-induced immunogenic cell death in non-small cell lung cancer |
| title_full |
Crizotinib-induced immunogenic cell death in non-small cell lung cancer |
| title_fullStr |
Crizotinib-induced immunogenic cell death in non-small cell lung cancer |
| title_full_unstemmed |
Crizotinib-induced immunogenic cell death in non-small cell lung cancer |
| title_sort |
crizotinib-induced immunogenic cell death in non-small cell lung cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-04-01 |
| description |
Certain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell death and can potentiate the efficacy of immune checkpoint blockade. |
| url |
https://doi.org/10.1038/s41467-019-09415-3 |
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