Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work

Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work

The thyroid-stimulating hormone receptor (TSHR) is a member of the glycoprotein hormone receptors, a sub-group of class A G-protein-coupled receptors (GPCRs). TSHR and its endogenous ligand thyrotropin (TSH) are of essential importance for growth and function of the thyroid gland and proper function...

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Bibliographic Details
Main Authors: Gerd Krause, Gunnar Kleinau, Catherine L. Worth, Annika Kreuchwig, Heike Biebermann, Patrick Marcinkowski, Patrick Scheerer
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Endocrinology
Subjects:
thyroid-stimulating hormone receptor structure
signal transduction
homology models
glycoprotein hormone receptors
arrestin interaction
G-protein interaction
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00086/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2017.00086/full

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