High and Low Levels of an NTRK2-Driven Genetic Profile Affect Motor- and Cognition-Associated Frontal Gray Matter in Prodromal Huntington’s Disease

High and Low Levels of an NTRK2-Driven Genetic Profile Affect Motor- and Cognition-Associated Frontal Gray Matter in Prodromal Huntington’s Disease

This study assessed how BDNF (brain-derived neurotrophic factor) and other genes involved in its signaling influence brain structure and clinical functioning in pre-diagnosis Huntington’s disease (HD). Parallel independent component analysis (pICA), a multivariate method for identifying correlated p...

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Bibliographic Details
Main Authors: Jennifer A. Ciarochi, Jingyu Liu, Vince Calhoun, Hans Johnson, Maria Misiura, H. Jeremy Bockholt, Flor A. Espinoza, Arvind Caprihan, Sergey Plis, Jessica A. Turner, Jane S. Paulsen, the PREDICT-HD Investigators and Coordinators of the Huntington Study Group
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Brain Sciences
Subjects:
Huntington’s disease
brain-derived neurotrophic factor
tropomyosin receptor kinase B
supplementary motor
independent component analysis
Online Access:http://www.mdpi.com/2076-3425/8/7/116

Internet

http://www.mdpi.com/2076-3425/8/7/116

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