The Role of Soluble Uric Acid in Modulating Autophagy Flux and Inflammasome Activation during Bacterial Infection in Macrophages

Autophagy is a homeostatic process that regulates and recycles intracellular structures and is a host defense mechanism that facilitates bacterial clearance. Uric acid in plasma is a major antioxidant but in certain conditions acts as an inflammatory danger signal. The aim of this study is to invest...

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Bibliographic Details
Main Authors: Duha Al-Awad, Nada Al-Emadi, Marawan Abu-Madi, Asmaa A. Al-Thani, Susu M. Zughaier
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomedicines
Subjects:
Online Access:https://www.mdpi.com/2227-9059/8/12/598