Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition

Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition

In general, expression of transglutaminase 2 (TGase 2) is upregulated in renal cell carcinoma (RCC), resulting in p53 instability. Previous studies show that TGase 2 binds to p53 and transports it to the autophagosome. Knockdown or inhibition of TGase 2 in RCC induces p53-mediated apoptosis. Here, w...

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Bibliographic Details
Main Authors: Seon-Hyeong Lee, Won-Kyu Lee, Nayeon Kim, Joon Hee Kang, Kyung-Hee Kim, Seul-Gi Kim, Jae-Seon Lee, Soohyun Lee, Jongkook Lee, Jungnam Joo, Woo Sun Kwon, Sun Young Rha, Soo-Youl Kim
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cancers
Subjects:
streptonigrin
renal cell carcinoma
p53
apoptosis
transglutaminase 2
Online Access:https://www.mdpi.com/2072-6694/10/11/455

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https://www.mdpi.com/2072-6694/10/11/455

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