Association Between Air Pollution and Lung Lobar Emphysema in COPD
The development of emphysema has been linked to air pollution; however, the association of air pollution with the extent of lobar emphysema remains unclear. This study examined the association of particulate matter <2.5 μm in aerodynamic diameters (PM2.5) (≤2.5 μm), nitrogen dioxide (NO2), an...
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Frontiers Media S.A.
2021-09-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.705792/full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nguyen Thanh Tung Nguyen Thanh Tung Shu-Chuan Ho Yueh-Hsun Lu Yueh-Hsun Lu Tzu-Tao Chen Kang-Yun Lee Kang-Yun Lee Kuan-Yuan Chen Chih-Da Wu Chih-Da Wu Kian Fan Chung Han-Pin Kuo Huynh Nguyen Xuan Thao Hoang Ba Dung Tran Phan Chung Thuy Sheng-Ming Wu Sheng-Ming Wu Hsiao-Yun Kou Yueh-Lun Lee Hsiao-Chi Chuang Hsiao-Chi Chuang Hsiao-Chi Chuang |
spellingShingle |
Nguyen Thanh Tung Nguyen Thanh Tung Shu-Chuan Ho Yueh-Hsun Lu Yueh-Hsun Lu Tzu-Tao Chen Kang-Yun Lee Kang-Yun Lee Kuan-Yuan Chen Chih-Da Wu Chih-Da Wu Kian Fan Chung Han-Pin Kuo Huynh Nguyen Xuan Thao Hoang Ba Dung Tran Phan Chung Thuy Sheng-Ming Wu Sheng-Ming Wu Hsiao-Yun Kou Yueh-Lun Lee Hsiao-Chi Chuang Hsiao-Chi Chuang Hsiao-Chi Chuang Association Between Air Pollution and Lung Lobar Emphysema in COPD Frontiers in Medicine air pollution BODE computed tomography COPD LAA |
author_facet |
Nguyen Thanh Tung Nguyen Thanh Tung Shu-Chuan Ho Yueh-Hsun Lu Yueh-Hsun Lu Tzu-Tao Chen Kang-Yun Lee Kang-Yun Lee Kuan-Yuan Chen Chih-Da Wu Chih-Da Wu Kian Fan Chung Han-Pin Kuo Huynh Nguyen Xuan Thao Hoang Ba Dung Tran Phan Chung Thuy Sheng-Ming Wu Sheng-Ming Wu Hsiao-Yun Kou Yueh-Lun Lee Hsiao-Chi Chuang Hsiao-Chi Chuang Hsiao-Chi Chuang |
author_sort |
Nguyen Thanh Tung |
title |
Association Between Air Pollution and Lung Lobar Emphysema in COPD |
title_short |
Association Between Air Pollution and Lung Lobar Emphysema in COPD |
title_full |
Association Between Air Pollution and Lung Lobar Emphysema in COPD |
title_fullStr |
Association Between Air Pollution and Lung Lobar Emphysema in COPD |
title_full_unstemmed |
Association Between Air Pollution and Lung Lobar Emphysema in COPD |
title_sort |
association between air pollution and lung lobar emphysema in copd |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2021-09-01 |
description |
The development of emphysema has been linked to air pollution; however, the association of air pollution with the extent of lobar emphysema remains unclear. This study examined the association of particulate matter <2.5 μm in aerodynamic diameters (PM2.5) (≤2.5 μm), nitrogen dioxide (NO2), and ozone (O3) level of exposure with the presence of emphysema in 86 patients with chronic obstructive pulmonary disease (COPD). Exposure to the air pollution estimated using the land-use regression model was associated with lung function, BODE (a body mass index, degree of obstruction, dyspnea severity, and exercise capacity index) quartiles, and emphysema measured as low-attenuation areas on high-resolution CT (HR-CT) lung scans. Using paraseptal emphysema as the reference group, we observed that a 1 ppb increase in O3 was associated with a 1.798-fold increased crude odds ratio of panlobular emphysema (p < 0.05). We observed that PM2.5 was associated with BODE quartiles, modified Medical Research Council (mMRC) dyspnea score, and exercise capacity (all p < 0.05). We found that PM2.5, NO2, and O3 were associated with an increased degree of upper lobe emphysema and lower lobe emphysema (all p < 0.05). Furthermore, we observed that an increase in PM2.5, NO2, and O3 was associated with greater increases in upper lobe emphysema than in lower lobe emphysema. In conclusion, exposure to O3 can be associated with a higher risk of panlobular emphysema than paraseptal emphysema in patients with COPD. Emphysema severity in lung lobes, especially the upper lobes, may be linked to air pollution exposure in COPD. |
topic |
air pollution BODE computed tomography COPD LAA |
url |
https://www.frontiersin.org/articles/10.3389/fmed.2021.705792/full |
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doaj-23b7dc6f309a4350b872062023df88432021-09-21T04:59:15ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-09-01810.3389/fmed.2021.705792705792Association Between Air Pollution and Lung Lobar Emphysema in COPDNguyen Thanh Tung0Nguyen Thanh Tung1Shu-Chuan Ho2Yueh-Hsun Lu3Yueh-Hsun Lu4Tzu-Tao Chen5Kang-Yun Lee6Kang-Yun Lee7Kuan-Yuan Chen8Chih-Da Wu9Chih-Da Wu10Kian Fan Chung11Han-Pin Kuo12Huynh Nguyen Xuan Thao13Hoang Ba Dung14Tran Phan Chung Thuy15Sheng-Ming Wu16Sheng-Ming Wu17Hsiao-Yun Kou18Yueh-Lun Lee19Hsiao-Chi Chuang20Hsiao-Chi Chuang21Hsiao-Chi Chuang22International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanOtorhinolaryngology Department, Cho Ray Hospital, Ho Chi Minh City, VietnamSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Radiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDepartment of Geomatics, National Cheng Kung University, Tainan City, TaiwanNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan0National Heart and Lung Institute, Imperial College London, London, United KingdomDivision of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan1Otorhinolaryngology Department, Ho Chi Minh City University of Medicine and Pharmacy, Ho Chi Minh City, VietnamOtorhinolaryngology Department, Cho Ray Hospital, Ho Chi Minh City, Vietnam2Otorhinolaryngology Department, Faculty of Medicine, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, VietnamDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan3Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan4Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, TaiwanThe development of emphysema has been linked to air pollution; however, the association of air pollution with the extent of lobar emphysema remains unclear. This study examined the association of particulate matter <2.5 μm in aerodynamic diameters (PM2.5) (≤2.5 μm), nitrogen dioxide (NO2), and ozone (O3) level of exposure with the presence of emphysema in 86 patients with chronic obstructive pulmonary disease (COPD). Exposure to the air pollution estimated using the land-use regression model was associated with lung function, BODE (a body mass index, degree of obstruction, dyspnea severity, and exercise capacity index) quartiles, and emphysema measured as low-attenuation areas on high-resolution CT (HR-CT) lung scans. Using paraseptal emphysema as the reference group, we observed that a 1 ppb increase in O3 was associated with a 1.798-fold increased crude odds ratio of panlobular emphysema (p < 0.05). We observed that PM2.5 was associated with BODE quartiles, modified Medical Research Council (mMRC) dyspnea score, and exercise capacity (all p < 0.05). We found that PM2.5, NO2, and O3 were associated with an increased degree of upper lobe emphysema and lower lobe emphysema (all p < 0.05). Furthermore, we observed that an increase in PM2.5, NO2, and O3 was associated with greater increases in upper lobe emphysema than in lower lobe emphysema. In conclusion, exposure to O3 can be associated with a higher risk of panlobular emphysema than paraseptal emphysema in patients with COPD. Emphysema severity in lung lobes, especially the upper lobes, may be linked to air pollution exposure in COPD.https://www.frontiersin.org/articles/10.3389/fmed.2021.705792/fullair pollutionBODEcomputed tomographyCOPDLAA |