A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate

A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate

We have developed a new method for automated production of 2-[18F]fluoroethyl tosylate ([18F]FETos) that enables 18F-alkylation to provide PET tracers with high chemical purity. The method is based on the removal of excess ethylene glycol bistosylate precursor by precipitation and subsequent filtrat...

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Bibliographic Details
Main Authors: Gjermund Henriksen, Frode Willoch, János Marton, Bent W. Schoultz, Brian J. Reed
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Molecules
Subjects:
2-[18F]fluoroethyl tosylate
18F-fluoroalkylation
PET
opioid receptors
automation
solid phase extraction
Online Access:http://www.mdpi.com/1420-3049/18/6/7271

Internet

http://www.mdpi.com/1420-3049/18/6/7271

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