The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.

The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.

Patients affected by chronic inflammatory disorders display high amounts of soluble CD95L. This homotrimeric ligand arises from the cleavage by metalloproteases of its membrane-bound counterpart, a strong apoptotic inducer. In contrast, the naturally processed CD95L is viewed as an apoptotic antagon...

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Bibliographic Details
Main Authors: Sébastien Tauzin, Benjamin Chaigne-Delalande, Eric Selva, Nadine Khadra, Sophie Daburon, Cécile Contin-Bordes, Patrick Blanco, Jacques Le Seyec, Thomas Ducret, Laurent Counillon, Jean-François Moreau, Paul Hofman, Pierre Vacher, Patrick Legembre
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3119658?pdf=render

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http://europepmc.org/articles/PMC3119658?pdf=render

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